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本文引用的文献

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Bevacizumab in Combination with Platinum-Based Chemotherapy in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with or without Brain Metastases: A French Cohort Study (EOLE).贝伐单抗联合铂类化疗用于有或无脑转移的晚期非鳞状非小细胞肺癌患者：一项法国队列研究（EOLE）
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Bevacizumab as an effective treatment for radiation necrosis after radiotherapy for melanoma brain metastases.贝伐单抗作为黑色素瘤脑转移瘤放疗后放射性坏死的有效治疗方法。
Melanoma Res. 2017 Dec;27(6):580-584. doi: 10.1097/CMR.0000000000000389.
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Inhibition of VEGF and Angiopoietin-2 to Reduce Brain Metastases of Breast Cancer Burden.抑制血管内皮生长因子和血管生成素-2以减轻乳腺癌脑转移负担。
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Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO).实体瘤脑转移的诊断与治疗：欧洲神经肿瘤学会（EANO）指南
Neuro Oncol. 2017 Feb 1;19(2):162-174. doi: 10.1093/neuonc/now241.
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Bevacizumab for the Treatment of Radiation-Induced Cerebral Necrosis: A Systematic Review of the Literature.贝伐单抗治疗放射性脑坏死：文献系统评价
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Bevacizumab, pemetrexed and carboplatin in first-line treatment of non-small cell lung cancer patients: Focus on patients with brain metastases.贝伐单抗、培美曲塞和卡铂用于非小细胞肺癌患者的一线治疗：聚焦脑转移患者。
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7
Palliative Resection of Metastatic Brain Tumors Previously Treated by Stereotactic Radiosurgery.先前接受立体定向放射外科治疗的转移性脑肿瘤的姑息性切除术。
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Descriptive statistical analysis of a real life cohort of 2419 patients with brain metastases of solid cancers.对2419例实体癌脑转移患者的真实队列进行描述性统计分析。
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脑转移瘤的抗血管生成治疗

Anti-angiogenic therapies in brain metastases.

作者信息

Berghoff Anna S, Preusser Matthias

机构信息

Department of Medicine I and Comprehensive Cancer Center Central Nervous System Tumours Unit (CCC-CNS), Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

出版信息

Memo. 2018;11(1):14-17. doi: 10.1007/s12254-018-0384-2. Epub 2018 Feb 2.

DOI:10.1007/s12254-018-0384-2
PMID:29606977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5862919/
Abstract

Brain metastases are a major challenge in modern oncology, as treatment options upon the diagnosis of symptomatic brain metastases are limited. Neo-angiogenesis was identified as a hallmark of brain metastasis development and inhibition using anti-angiogenic therapy might therefore be an experimental promising preventive as well as therapeutic approach. The current review will summarize the current available data on the efficacy of neo-angiogenic therapies in patients with brain metastases.

摘要

脑转移瘤是现代肿瘤学中的一项重大挑战，因为对于有症状的脑转移瘤，诊断后的治疗选择有限。新血管生成被确定为脑转移瘤发展的一个标志，因此使用抗血管生成疗法进行抑制可能是一种有前景的实验性预防和治疗方法。本综述将总结目前关于新血管生成疗法对脑转移瘤患者疗效的现有数据。