脑转移瘤的抗血管生成治疗
Anti-angiogenic therapies in brain metastases.
作者信息
Berghoff Anna S, Preusser Matthias
机构信息
Department of Medicine I and Comprehensive Cancer Center Central Nervous System Tumours Unit (CCC-CNS), Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
出版信息
Memo. 2018;11(1):14-17. doi: 10.1007/s12254-018-0384-2. Epub 2018 Feb 2.
Abstract
Brain metastases are a major challenge in modern oncology, as treatment options upon the diagnosis of symptomatic brain metastases are limited. Neo-angiogenesis was identified as a hallmark of brain metastasis development and inhibition using anti-angiogenic therapy might therefore be an experimental promising preventive as well as therapeutic approach. The current review will summarize the current available data on the efficacy of neo-angiogenic therapies in patients with brain metastases.
摘要
脑转移瘤是现代肿瘤学中的一项重大挑战，因为对于有症状的脑转移瘤，诊断后的治疗选择有限。新血管生成被确定为脑转移瘤发展的一个标志，因此使用抗血管生成疗法进行抑制可能是一种有前景的实验性预防和治疗方法。本综述将总结目前关于新血管生成疗法对脑转移瘤患者疗效的现有数据。
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