Department of Pediatrics, Severance Children's Hospital, Severance Pediatric Liver Research Group, Yonsei University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2018 Apr 2;33(14):e109. doi: 10.3346/jkms.2018.33.e109.
Nonalcoholic fatty liver disease (NAFLD) has become prevalent worldwide in the last decade. However, the recent prevalence of NAFLD in adolescents has not yet been investigated in Korea.
Data were obtained from 1,416 participants aged 10-18 years from the Korea National Health and Nutrition Examination Survey conducted in 2010 and 2015. Systolic blood pressure (SBP), diastolic blood pressure (DBP), height, weight, waist circumference (WC), body mass index (BMI), fasting glucose, total cholesterol, high-density lipoprotein (HDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT) level, waist-to-height ratio (WHtR), and pediatric NAFLD fibrosis index (PNFI) were analyzed.
SBP, weight, WC, BMI, WHtR, and total cholesterol level were significantly higher in 2015 than in 2010. Prevalence of NAFLD (BMI ≥ 85th percentile plus ALT > 30 U/L for boys and ALT > 19 U/L for girls) were 4.7% in 2010 and 5.9% in 2015 (P = 0.360). Using various cutoffs for the ALT level (> 40, > 30, > 25.8 U/L for boys and >22.1 U/L for girls) NAFLD prevalence rates were 3.0%, 4.1%, and 5.5% in 2010; 2.9%, 5.0%, and 7.1% in 2015, respectively (P = 0.899, 0.469, and 0.289). Boys had a higher SBP, DBP, height, weight, WC, BMI, WHtR, fasting glucose, total cholesterol, ALT, and lower HDL level than girls. The probability of liver fibrosis using the PNFI varies between 21.3% and 24.5% among NAFLD participants (P < 0.001).
The Korean society needs to quickly control the increasing prevalence of NAFLD in adolescents and reduce its complications.
非酒精性脂肪性肝病（NAFLD）在过去十年中在全球范围内变得普遍。然而，最近在韩国还没有调查青少年 NAFLD 的流行情况。
数据来自于 2010 年和 2015 年进行的韩国国家健康和营养检查调查中的 1416 名 10-18 岁的参与者。分析了收缩压（SBP）、舒张压（DBP）、身高、体重、腰围（WC）、体重指数（BMI）、空腹血糖、总胆固醇、高密度脂蛋白（HDL）、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）水平、腰高比（WHtR）和儿科非酒精性脂肪性肝病纤维化指数（PNFI）。
2015 年 SBP、体重、WC、BMI、WHtR 和总胆固醇水平均显著高于 2010 年。2010 年和 2015 年 NAFLD 的患病率（BMI≥85 百分位加 ALT＞30 U/L 男，ALT＞19 U/L 女）分别为 4.7%和 5.9%（P=0.360）。使用 ALT 水平的不同切点（＞40、＞30、＞25.8 U/L 男和＞22.1 U/L 女），2010 年的 NAFLD 患病率分别为 3.0%、4.1%和 5.5%；2015 年分别为 2.9%、5.0%和 7.1%（P=0.899、0.469 和 0.289）。男孩的 SBP、DBP、身高、体重、WC、BMI、WHtR、空腹血糖、总胆固醇、ALT 水平较高，HDL 水平较低。使用 PNFI，NAFLD 参与者的肝纤维化概率在 21.3%至 24.5%之间变化（P＜0.001）。
韩国社会需要迅速控制青少年中 NAFLD 患病率的上升，并减少其并发症。
