Department of Chemistry , Indian Institute of Technology Madras , Chennai , Tamil Nadu 600036 , India.
J Org Chem. 2018 Apr 20;83(8):4692-4702. doi: 10.1021/acs.joc.8b00463. Epub 2018 Apr 5.
The carbene migratory insertion involving a domino reaction by highly stable, reusable, and binaphthyl-stabilized Pd-nanoparticles (Pd-BNP) is disclosed. The reaction was catalyzed by 2 mol % of a heterogeneous Pd-BNP catalyst under external ligand-free conditions, and it afforded 3-aryl-substituted indanone derivatives in up to a 90% yield with exclusive E-selectivity. Furthermore, a one-pot reaction and derivatization of indanone derivatives were also successfully demonstrated.
本文公开了一种涉及重氮反应的卡宾迁移插入反应，该反应由高稳定性、可重复使用的双萘基稳定的 Pd-纳米粒子（Pd-BNP）引发。在无外加配体的条件下，该反应以 2 mol%的非均相 Pd-BNP 催化剂为催化剂，以高达 90%的收率和 E-选择性得到了 3-芳基取代的茚满酮衍生物。此外，还成功地进行了一锅反应和茚满酮衍生物的衍生化。
