通过 Rh(III)-催化的苯甲酰乙腈的双重 C-H 活化构建（二氢）萘并[1,8-bc]吡喃。
Construction of (Dihydro)naphtho[1,8- bc]pyrans via Rh(III)-Catalyzed Twofold C-H Activation of Benzoylacetonitriles.
机构信息
Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering , Henan Normal University , Xinxiang 453007 , China.
Dalian Institute of Chemical Physics , Chinese Academy of Sciences , Dalian 116023 , China.
出版信息
Org Lett. 2018 Apr 20;20(8):2160-2163. doi: 10.1021/acs.orglett.8b00420. Epub 2018 Apr 2.
Rh(III)-catalyzed cascade C-H activation of benzoylacetonitriles and annulation with sulfoxonium ylides was realized, leading to selective synthesis of naphthols, 2,3-dihydronaphtho[1,8- bc]pyrans, and naphtho[1,8- bc]pyrans. This step-economic reaction proceeded efficiently under mild and redox-neutral conditions via multiple C-H activations.
铑（III）催化的苯甲酰乙腈的级联 C-H 活化与亚砜叶立德的环化反应得到了实现，从而选择性地合成了萘酚、2,3-二氢萘并[1,8-bc]吡喃和萘并[1,8-bc]吡喃。该步经济性反应在温和和氧化还原中性条件下通过多次 C-H 活化高效进行。
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