铑(III)催化通过亚砜叶立德的 C-H 活化合成萘酚。
Rhodium(III)-Catalyzed Synthesis of Naphthols via C-H Activation of Sulfoxonium Ylides.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
University of Chinese Academy of Sciences , Beijing 100049, China.
出版信息
Org Lett. 2017 Aug 18;19(16):4307-4310. doi: 10.1021/acs.orglett.7b01974. Epub 2017 Aug 7.
PMID:28783365
Abstract
Direct and efficient synthesis of 1-naphthols has been realized via Rh(III)-catalyzed C-H activation of sulfoxonium ylides and subsequent annulation with alkynes, where the sulfoxonium ylide functioned as a new traceless bifunctional directing group. This reaction occurred under redox-neutral conditions with a broad substrate scope.
摘要
通过 Rh(III)催化的亚砜叶立德的 C-H 活化和随后与炔烃的环化反应，实现了 1-萘酚的直接和高效合成，其中亚砜叶立德作为一种新的无痕迹双功能导向基团。该反应在氧化还原中性条件下进行，具有广泛的底物范围。
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