a Biomodulation, Department of Agricultural Biotechnology , Seoul National University , Seoul , Republic of Korea.
b Cancer Research Institute , Seoul National University College of Medicine , Seoul , Republic of Korea.
Free Radic Res. 2018 Dec;52(11-12):1271-1287. doi: 10.1080/10715762.2018.1459594. Epub 2018 Apr 19.
Mitochondria, evolutionally acquired symbionts of eukaryotic cells, are essential cytoplasmic organelles. They are structurally dynamic organelles that continually go through fission and fusion processes in response to various stimuli. Tumour tissue is composed of not just cancer cells but also various cell types like fibroblasts, mesenchymal stem and immune cells. Mitochondrial dynamics of cancer cells has been shown to be significantly affected by features of tumour microenvironment such as hypoxia, inflammation and energy deprivation. The interactions of cancer cells with tumour microenvironment like hypoxia give rise to the inter- and intratumoural heterogeneity, causing chemoresistance. In this review, we will focus on the chemoresistance by tumoural heterogeneity in relation to mitochondrial dynamics of cancer cells. Recent findings in molecular mechanisms involved in the control of mitochondrial dynamics as well as the impact of mitochondrial dynamics on drug sensitivity in cancer are highlighted in the current review.
线粒体是真核细胞进化获得的共生体，是重要的细胞质细胞器。它们是结构动态的细胞器，会根据各种刺激不断经历分裂和融合过程。肿瘤组织不仅由癌细胞组成，还包括成纤维细胞、间充质干细胞和免疫细胞等各种细胞类型。已经表明，癌细胞的线粒体动力学会受到肿瘤微环境的特征（如缺氧、炎症和能量剥夺）的显著影响。癌细胞与肿瘤微环境（如缺氧）的相互作用导致肿瘤内和肿瘤间的异质性，从而导致化疗耐药性。在这篇综述中，我们将重点关注与癌细胞线粒体动力学相关的肿瘤异质性的化疗耐药性。本文强调了控制线粒体动力学的分子机制的最新发现，以及线粒体动力学对癌症药物敏感性的影响。
