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线粒体移植治疗疾病的最新进展。

Recent advances in mitochondrial transplantation to treat disease.

作者信息

Li Xiangling, Guan Yanjun, Li Chaochao, Cheng Haofeng, Bai Jun, Zhao Jinjuan, Wang Yu, Peng Jiang

机构信息

Institute of Orthopedics, The Fourth Medical Centre of Chinese PLA General Hospital; Beijing Key Lab of Regenerative Medicine in Orthopedics; Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing, China.

Department of Rehabilitation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

出版信息

Biomater Transl. 2025 Mar 25;6(1):4-23. doi: 10.12336/biomatertransl.2025.01.002. eCollection 2025.

DOI:10.12336/biomatertransl.2025.01.002
PMID:40313574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12041809/
Abstract

Mitochondrial transplantation (MT), an innovative regenerative technique widely used to treat diseases caused by mitochondrial dysfunction, shows great promise for clinical application. This procedure can increase the number of mitochondria and improve the function of damaged mitochondria, resulting in increased adenosine triphosphate levels, decreased reactive oxygen species production, improved Ca buffering capacity, modulated inflammatory response, and reduced apoptosis to protect cells, thus promoting tissue repair. In this review, we describe research advances in MT over the last five years, focusing on its application in treating various diseases, including ischaemic injuries (of the kidney, heart, lung, and liver), neurodegenerative disorders, spinal cord injury, sepsis, diabetes mellitus, stroke, and ultraviolet radiation injuries, as well as in procedures such as organ transplantation, focusing on instances where MT demonstrated good efficacy. We also cover the application of engineered mitochondria and mitochondrial combination therapies and present the latest advances in improving MT efficiency, as well as the current clinical applications and shortcomings of MT, aiming to provide a theoretical foundation for enhanced MT utilisation in the future.

摘要

线粒体移植（MT）是一种广泛用于治疗由线粒体功能障碍引起的疾病的创新性再生技术，具有巨大的临床应用前景。该过程可以增加线粒体数量并改善受损线粒体的功能，从而提高三磷酸腺苷水平、减少活性氧生成、增强钙缓冲能力、调节炎症反应并减少细胞凋亡以保护细胞，进而促进组织修复。在本综述中，我们描述了过去五年中线粒体移植的研究进展，重点关注其在治疗各种疾病中的应用，包括（肾脏、心脏、肺和肝脏的）缺血性损伤、神经退行性疾病、脊髓损伤、脓毒症、糖尿病、中风和紫外线辐射损伤，以及在器官移植等手术中的应用，重点关注线粒体移植显示出良好疗效的实例。我们还涵盖了工程化线粒体和线粒体联合疗法的应用，并介绍了提高线粒体移植效率的最新进展，以及线粒体移植目前的临床应用和不足之处，旨在为未来提高线粒体移植的利用率提供理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/864aac385a67/bt-06-01-4-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/32fadeef886f/bt-06-01-4-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/2aa872e8c060/bt-06-01-4-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/b64fe8df0188/bt-06-01-4-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/cb19c0162e12/bt-06-01-4-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/df69876a9e84/bt-06-01-4-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/864aac385a67/bt-06-01-4-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/32fadeef886f/bt-06-01-4-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/2aa872e8c060/bt-06-01-4-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/b64fe8df0188/bt-06-01-4-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/cb19c0162e12/bt-06-01-4-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e6b3/12041809/df69876a9e84/bt-06-01-4-g005.jpg
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引用本文的文献

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本文引用的文献

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Mitochondrial Transplantation Therapy Ameliorates Muscular Dystrophy in Mouse Model.线粒体移植疗法改善小鼠模型的肌肉萎缩症。
Biomolecules. 2024 Mar 7;14(3):316. doi: 10.3390/biom14030316.
2
Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis.工程化线粒体复合物的靶向移植通过增强巨噬细胞吞噬作用促进脊髓损伤后的功能恢复。
Bioact Mater. 2023 Oct 27;32:427-444. doi: 10.1016/j.bioactmat.2023.10.016. eCollection 2024 Feb.
3
Mesenchymal Stem Cell-Derived Mitochondria Enhance Extracellular Matrix-Derived Grafts for the Repair of Nerve Defect.
间充质干细胞来源的线粒体增强细胞外基质衍生移植物用于修复神经缺损
Adv Healthc Mater. 2024 Jan;13(3):e2302128. doi: 10.1002/adhm.202302128. Epub 2023 Nov 16.
4
Mitochondrial transplantation attenuates toxicity in rat renal proximal tubular cells caused by Favipiravir.线粒体移植减轻了法维拉韦对大鼠肾近端肾小管细胞的毒性。
J Pharm Pharmacol. 2023 Nov 23;75(11):1458-1466. doi: 10.1093/jpp/rgad079.
5
Mitochondrial transplantation ameliorates doxorubicin-induced cardiac dysfunction via activating glutamine metabolism.线粒体移植通过激活谷氨酰胺代谢改善阿霉素诱导的心脏功能障碍。
iScience. 2023 Sep 1;26(10):107790. doi: 10.1016/j.isci.2023.107790. eCollection 2023 Oct 20.
6
Mitochondria transfer as a potential therapeutic mechanism in Alzheimer's disease-like pathology.线粒体转移作为阿尔茨海默病样病变的一种潜在治疗机制。
Brain Res. 2023 Nov 15;1819:148544. doi: 10.1016/j.brainres.2023.148544. Epub 2023 Aug 22.
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