Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Department of Biostatistics, School of Public Health, The University of Tokyo, Tokyo, Japan.
Geriatr Gerontol Int. 2018 Jul;18(7):1108-1113. doi: 10.1111/ggi.13323. Epub 2018 Apr 2.
Aortic pulse wave velocity (PWV) is a strong predictor of all-cause mortality in later life. The present prospective study used repeated measures analysis to examine sex-specific age trends in brachial-ankle PWV (baPWV), identify baPWV trajectories and determine whether potential baPWV trajectories were associated with all-cause mortality among community-dwelling older Japanese.
A total of 1744 adults (mean age 71.0 years [SD 5.8 years]; 57.0% women) aged 65-90 years participated in annual geriatric health assessments during the period from April 2003 through July 2015. The average number of follow-up assessments was 4.3, and the total number of observations was 7419. We checked local registries to identify deaths from any cause; 289 (16.6%) participants died during the period through December 2015.
baPWV similarly and significantly increased with advancing age in men and women. We identified four distinct trajectory patterns (very high, high, moderate, and low) in adults aged 65-90 years, and these trajectories showed parallel increases. After adjusting for important confounders, participants in the moderate, high and very high baPWV trajectory groups had hazard ratios of 1.12 (95% CI 0.84-1.44), 1.04 (95% CI 0.74-1.45) and 1.98 (95% CI 1.20-3.29), respectively, for all-cause mortality, as compared with those in the low trajectory group.
baPWV increased with age in men and women, and there was no significance between sexes in later life. This prospective study identified four major baPWV trajectory patterns in community-dwelling older adults. Individuals in the very high baPWV trajectory group, especially younger seniors, had a higher mortality risk. Geriatr Gerontol Int 2018; 18: 1108-1113.
脉搏波速度（PWV）是预测晚年全因死亡率的强有力指标。本前瞻性研究采用重复测量分析，研究肱踝 PWV（baPWV）的性别特异性年龄趋势，确定 baPWV 轨迹，并确定潜在的 baPWV 轨迹是否与社区居住的日本老年人的全因死亡率相关。
共有 1744 名年龄在 65-90 岁（平均年龄 71.0 岁[标准差 5.8 岁]；57.0%为女性）的成年人参加了 2003 年 4 月至 2015 年 7 月期间的年度老年健康评估。平均随访评估次数为 4.3 次，总观察次数为 7419 次。我们检查了当地登记册，以确定任何原因导致的死亡；截至 2015 年 12 月，有 289 名（16.6%）参与者死亡。
baPWV 在男性和女性中均随年龄的增长而显著增加。我们在 65-90 岁的成年人中确定了四个不同的轨迹模式（非常高、高、中、低），这些轨迹呈平行增加。在校正了重要的混杂因素后，中、高和非常高的 baPWV 轨迹组的参与者发生全因死亡率的危险比分别为 1.12（95%CI 0.84-1.44）、1.04（95%CI 0.74-1.45）和 1.98（95%CI 1.20-3.29），与低轨迹组相比。
baPWV 在男性和女性中随年龄的增长而增加，而在晚年男女之间没有显著性差异。本前瞻性研究在社区居住的老年人中确定了四个主要的 baPWV 轨迹模式。非常高的 baPWV 轨迹组的个体，尤其是年轻的老年人，死亡风险更高。老年医学与老年病学杂志 2018；18：1108-1113。
