环境光下的瞳孔异常与阿片类药物反应性预测：2例具有挑战性急性疼痛状况患者管理中的效用病例报告
Pupillary Unrest in Ambient Light and Prediction of Opioid Responsiveness: Case Report on Its Utility in the Management of 2 Patients With Challenging Acute Pain Conditions.
作者信息
McKay Rachel Eshima, Neice Andrew E, Larson Merlin D
机构信息
From the Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California.
Department of Anesthesiology and Perioperative Medicine, Oregon Health Sciences University, Portland, Oregon.
出版信息
A A Pract. 2018 May 15;10(10):279-282. doi: 10.1213/XAA.0000000000000710.
Pupillary unrest in ambient light (PUAL), the normal pattern of pupil diameter fluctuation present in awake humans, has been proposed as a marker of central opioid effect. We report 2 cases in which PUAL identified the appropriate pain management for 2 patients, each with unique, challenging acute pain conditions. In both cases, PUAL accurately predicted opioid responsiveness, suggesting an effective, individualized analgesic approach for both patients.
环境光下的瞳孔波动（PUAL）是清醒人类中存在的正常瞳孔直径波动模式，已被提议作为中枢阿片类药物作用的标志物。我们报告了2例病例，其中PUAL为2名患者确定了合适的疼痛管理方案，每名患者都有独特且具有挑战性的急性疼痛情况。在这两例病例中，PUAL都准确预测了阿片类药物的反应性，为两名患者都提出了一种有效、个体化的镇痛方法。
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