Strauss A L, Kedra A W
Department of Explorations Fonctionnelles, Hopital Lariboisiere, Paris, France.
Med Instrum. 1987 Oct;21(5):255-61.
A novel, noninvasive method to determine simultaneously ophthalmic artery pressure (OAP) and flow direction, called ophthalmomanometry-Doppler, is presented. This technique uses a device consisting of a chamber with an apperture hermetically adaptable to the orbital borders. The chamber is equipped with a Doppler probe and an arrival pipe for compressed air connected to a manometer. The OAP measurement procedure consists of applying a pressure in the chamber while the Doppler probe detects periorbital Doppler signals. The systolic OAP corresponds to the Doppler signal disappearance during chamber pressure increase. Studies performed on normal subjects with direct recording of the internal carotid artery pressure (ICP) and indirect determination of the brachial artery pressure (BAP) demonstrated that OAP values assessed by the ophthalmomanometry-Doppler device were highly correlated with simultaneous ipsilateral intra-arterial systolic ICP measurements (r = 0.95, n = 10) and with simultaneous recordings of the BAP (r = 0.85, n = 40). The ophthalmic pressure index (OAP/ICP and OAP/BAP ratio, respectively) ranged from 0.60-0.77 with a mean (+/- SD) of 0.68 (+/- 0.04) in the 50 normal subjects. Preliminary clinical trials show diminished OAP/BAP ratios in patients with occlusive carotid disease ipsilateral to hemodynamically significant lesions. The values obtained on these normal subjects provide baseline data for further investigation of pathologic conditions. This new procedure is simple, convenient, rapid, and safe and provides reproducible information on both OAP and flow parameters, which are important indices in the evaluation of severe carotid artery disease.
本文介绍了一种名为眼压计 - 多普勒的新型非侵入性方法，可同时测定眼动脉压（OAP）和血流方向。该技术使用一种装置，该装置由一个带有与眼眶边界紧密适配的小孔的腔室组成。腔室配备有一个多普勒探头和一个连接到压力计的压缩空气输入管。OAP测量程序包括在腔室内施加压力，同时多普勒探头检测眶周多普勒信号。收缩期OAP对应于腔室压力增加时多普勒信号的消失。对正常受试者进行的研究，直接记录颈内动脉压（ICP）并间接测定肱动脉压（BAP），结果表明，通过眼压计 - 多普勒装置评估的OAP值与同侧动脉内收缩期ICP同步测量值高度相关（r = 0.95，n = 10），与BAP同步记录值高度相关（r = 0.85，n = 40）。在50名正常受试者中，眼压指数（分别为OAP/ICP和OAP/BAP比值）范围为0.60 - 0.77，平均值（±标准差）为0.68（±0.04）。初步临床试验表明，在患有与血流动力学显著病变同侧的闭塞性颈动脉疾病的患者中，OAP/BAP比值降低。在这些正常受试者身上获得的值为进一步研究病理状况提供了基线数据。这种新方法简单、方便、快速且安全，可提供关于OAP和血流参数的可重复信息，这些参数是评估严重颈动脉疾病的重要指标。
