McLennan I S
Department of Behavioural Biology, Australian National University, Canberra City.
Muscle Nerve. 1987 Nov-Dec;10(9):801-9. doi: 10.1002/mus.880100905.
Inhibition of prostaglandin synthesis in chicken embryos generated a myopathy characterized by ringbinden, loss of Z disks and thick and thin filaments from the myofibrillar apparatus. During the early stages of myogenesis there was also abnormal clustering and contacts between the developing myotubes. This disruption of myofibrillar apparatus occurred in both primary and secondary myotubes. There was also a slight increase in the proportion of type 1 fibers, which resulted from a selective absence of type 2 fibers. The number of motoneurons in the lumbar spinal cord was normal. This, along with the nature of the disruption of the myofibrillar apparatus, was taken as an indication that the generation of this myopathy was not secondary to abnormal motoneuron development.
抑制鸡胚中的前列腺素合成会产生一种肌病，其特征为肌纤维束缠结、Z线消失以及肌原纤维装置中的粗细肌丝缺失。在肌生成的早期阶段，发育中的肌管之间也存在异常聚集和接触。这种肌原纤维装置的破坏在初级和次级肌管中均有发生。此外，1型纤维的比例略有增加，这是由于2型纤维选择性缺失所致。腰脊髓中的运动神经元数量正常。结合肌原纤维装置破坏的性质，这被视为该肌病并非继发于运动神经元异常发育的一个迹象。
