McLennan I S
Exp Neurol. 1985 Sep;89(3):616-21. doi: 10.1016/0014-4886(85)90011-1.
Administration of inhibitors of prostaglandin synthetase to chicken embryos produced myopathies in their skeletal muscles which were characterized by ringbinden, hypercontraction, loss of Z disks, M bands, and thick and thin filaments. The effects of the inhibitors were reversed by administration of PGE1. The pathology of the myopathy induced in the chicken embryos was identical to that observed in human muscular dystrophy and had some features in common with other congenital myopathies. Altered prostaglandin function may therefore be directly or indirectly involved in the pathogenesis of congenital myopathies.
给鸡胚注射前列腺素合成酶抑制剂会导致其骨骼肌出现肌病，其特征为环状结构、过度收缩、Z盘、M带以及粗细肌丝缺失。通过注射PGE1可逆转抑制剂的作用效果。鸡胚中诱发的肌病病理学特征与人类肌肉萎缩症中观察到的相同，并且与其他先天性肌病有一些共同特征。因此，前列腺素功能的改变可能直接或间接参与先天性肌病的发病机制。
