Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Neurobiol Aging. 2018 Jul;67:23-30. doi: 10.1016/j.neurobiolaging.2018.03.003. Epub 2018 Mar 9.
Tooth loss has been related to cognitive impairment; however, its relation to structural brain differences in humans is unknown. Dementia-free participants (n = 2715) of age ≥60 years were followed up for up to 9 years. A subsample (n = 394) underwent magnetic resonance imaging at baseline. Information on tooth loss was collected at baseline, and cognitive function was assessed using the Mini-Mental State Examination at baseline and at follow-ups. Data were analyzed using linear mixed effects models and linear regression models. At baseline, 404 (14.9%) participants had partial tooth loss, and 206 (7.6%) had complete tooth loss. Tooth loss was significantly associated with a steeper cognitive decline (β: -0.18, 95% confidence interval [CI]: -0.24 to -0.11) and remained significant after adjusting for or stratifying by potential confounders. In cross-sectional analyses, persons with complete or partial tooth loss had significantly lower total brain volume (β: -28.89, 95% CI: -49.33 to -8.45) and gray matter volume (β: -22.60, 95% CI: -38.26 to -6.94). Thus, tooth loss may be a risk factor for accelerated cognitive aging.
牙齿缺失与认知障碍有关；然而，其与人类大脑结构差异的关系尚不清楚。无痴呆症的参与者（n=2715）年龄≥60 岁，随访时间长达 9 年。一个亚组（n=394）在基线时接受了磁共振成像。在基线时收集牙齿缺失信息，使用简易精神状态检查在基线和随访时评估认知功能。使用线性混合效应模型和线性回归模型进行数据分析。基线时，404 名（14.9%）参与者有部分牙齿缺失，206 名（7.6%）有完全牙齿缺失。牙齿缺失与认知能力下降幅度更大显著相关（β：-0.18，95%置信区间[CI]：-0.24 至-0.11），并在调整潜在混杂因素或分层后仍然显著。在横断面分析中，完全或部分牙齿缺失的人总脑容量（β：-28.89，95%CI：-49.33 至-8.45）和灰质体积（β：-22.60，95%CI：-38.26 至-6.94）明显较低。因此，牙齿缺失可能是加速认知衰老的一个风险因素。
