Lockitch G, Singh V K, Puterman M L, Godolphin W J, Sheps S, Tingle A J, Wong F, Quigley G
Department of Pathology, University of British Columbia, Vancouver, Canada.
Pediatr Res. 1987 Nov;22(5):536-40. doi: 10.1203/00006450-198711000-00013.
Abnormalities of humoral and cell-mediated immunity have been described in Down syndrome but reported findings have been inconsistent. Confounding factors have included age, institutional versus home life, hepatitis B antigenemia, and zinc deficiency. To clarify this problem, we studied 64 children with Down syndrome (DS) compared with an age-matched control group. All children had always lived at home. All the DS children were negative for hepatitis B surface antigen. Serum zinc concentration in the DS group was on average 12 micrograms/dl lower than age-matched control children. They also had significantly lower levels of immunoglobulin M, total lymphocyte count, T and B lymphocytes, and T helper and suppressor cells. In vitro lymphocyte response to phytohemagglutinin and concanavalin A was significantly reduced at all ages in the DS group. Lymphocyte response to pokeweed mitogen increased with age in control children but decreased in the DS children. By 18 yr, the mean response for DS was 60000 cpm lower than controls. The DS group had significantly higher concentrations of immunoglobulins A and G than controls and the difference increased with age. Complement fractions C3 and C4 were also higher in the DS group at all ages. The number of HNK-1 positive cells was higher in the DS group than controls at all ages. When hepatitis and institutionalization are excluded as confounding factors, DS children still differ in both humoral and cell-mediated immunity from an age-matched control group.
唐氏综合征患者存在体液免疫和细胞介导免疫异常，但报道的研究结果并不一致。混杂因素包括年龄、机构生活与家庭生活、乙肝抗原血症和锌缺乏。为了阐明这一问题，我们对64名唐氏综合征（DS）患儿与年龄匹配的对照组进行了研究。所有儿童均一直生活在家中。所有DS患儿乙肝表面抗原均为阴性。DS组血清锌浓度平均比年龄匹配的对照儿童低12微克/分升。他们的免疫球蛋白M、总淋巴细胞计数、T和B淋巴细胞以及辅助性T细胞和抑制性T细胞水平也显著较低。DS组各年龄段对植物血凝素和刀豆球蛋白A的体外淋巴细胞反应均显著降低。对照儿童对商陆有丝分裂原的淋巴细胞反应随年龄增加，而DS患儿则降低。到18岁时，DS组的平均反应比对照组低60000 cpm。DS组免疫球蛋白A和G的浓度显著高于对照组，且差异随年龄增加。各年龄段DS组的补体成分C3和C4也较高。各年龄段DS组HNK-1阳性细胞数量均高于对照组。排除肝炎和机构生活作为混杂因素后，DS患儿在体液免疫和细胞介导免疫方面仍与年龄匹配的对照组存在差异。
