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女贞子对去卵巢大鼠雌激素受体表达有调节作用且无子宫营养效应。

Fructus Ligustri Lucidi modulates estrogen receptor expression with no uterotrophic effect in ovariectomized rats.

作者信息

Tang Yu-Qing, Li Cheng, Sun Xue-Jiao, Liu Yi, Wang Xi-Ting, Guo Yu-Bo, Wang Li-Li, Ma Ru-Feng, Niu Jian-Zhao, Fu Min, Zhang Dong-Wei, Li Yu

机构信息

Traditional Chinese Medicine School, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.

Chinese Material Medica School, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.

出版信息

BMC Complement Altern Med. 2018 Apr 2;18(1):118. doi: 10.1186/s12906-018-2171-3.

DOI:10.1186/s12906-018-2171-3
PMID:29609586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5880075/
Abstract

BACKGROUND

Accumulating evidence suggests that Fructus Ligustri Lucidi (FLL) plays a beneficial role in preventing the development of osteoporosis. However, the effects of FLL on estrogen receptor (ER) α and ERβ expressions remain unknown. Therefore, in the current study we attempted to probe into the effects of FLL on ERα and ERβ expressions in femurs, tibias and uteri of ovariectomized (OVX) rats.

METHODS

The OVX rats were orally administrated with FLL water extract (3.5 g/kg/day) for 12 weeks. The uteri, femurs, tibias and serum were harvested from rats. The serum levels of estrogen (E), luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined by ELISA. The expressions of ERα and ERβ in the femurs and tibias as well as uteri were analysed by western blot and immunohistochemical staining.

RESULTS

FLL treatment did not increase uterus relative weight in OVX rats. Further, FLL treatment increased ERα expression in the femurs and tibias, and enhanced ERβ expression in the uteri of OVX rats. However, the resulted expression of ERα was stronger than that of ERβ in OVX rats in response to FLL treatment. Meanwhile, administration with FLL to OVX rats increased FSH and LH but did not increase E level in the serum.

CONCLUSION

FLL treatment shows tissue selection on ERα and ERβ expressions in the femurs and tibias as well as uteri of OVX rats without uterotrophic effect, which may offer the scientific evidence of the efficiency and safety of its clinical application.

摘要

背景

越来越多的证据表明，女贞子在预防骨质疏松症的发展中发挥有益作用。然而，女贞子对雌激素受体（ER）α和ERβ表达的影响尚不清楚。因此，在本研究中，我们试图探讨女贞子对去卵巢（OVX）大鼠股骨、胫骨和子宫中ERα和ERβ表达的影响。

方法

给OVX大鼠口服女贞子水提取物（3.5 g/kg/天），持续12周。从大鼠身上采集子宫、股骨、胫骨和血清。采用酶联免疫吸附测定法（ELISA）测定血清中雌激素（E）、黄体生成素（LH）和卵泡刺激素（FSH）的水平。通过蛋白质免疫印迹法和免疫组织化学染色分析股骨、胫骨以及子宫中ERα和ERβ的表达。

结果

女贞子处理未增加OVX大鼠的子宫相对重量。此外，女贞子处理增加了OVX大鼠股骨和胫骨中ERα的表达，并增强了子宫中ERβ的表达。然而，在女贞子处理的OVX大鼠中，ERα的表达强于ERβ。同时，给OVX大鼠服用女贞子可增加血清中FSH和LH水平，但未增加E水平。

结论

女贞子处理对OVX大鼠股骨、胫骨和子宫中ERα和ERβ的表达具有组织选择性，且无促子宫生长作用，这可能为其临床应用的有效性和安全性提供科学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/0bb2560bb3c9/12906_2018_2171_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/458a04e82e86/12906_2018_2171_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/72223e6de7a4/12906_2018_2171_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/24a4cc2802a8/12906_2018_2171_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/176ba144461d/12906_2018_2171_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/3ece37c99c12/12906_2018_2171_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/0bb2560bb3c9/12906_2018_2171_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/458a04e82e86/12906_2018_2171_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/72223e6de7a4/12906_2018_2171_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/24a4cc2802a8/12906_2018_2171_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/176ba144461d/12906_2018_2171_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/3ece37c99c12/12906_2018_2171_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c78c/5880075/0bb2560bb3c9/12906_2018_2171_Fig6_HTML.jpg

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