Lee Chien-Ying, Su Chun-Hung, Chiang Chien-Ying, Wu Chun-Nan, Kuan Yu-Hsiang
Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan.
Evid Based Complement Alternat Med. 2021 Feb 17;2021:6667011. doi: 10.1155/2021/6667011. eCollection 2021.
Despite minoxidil and finasteride already being approved by the Food and Drug Administration (FDA) for the treatment of hair loss, it is important to identify new and innovative treatments for hair loss, such as looking for a solution in Chinese herbal medicine. One such treatment to consider is BeauTop (BT), whose primary ingredients include (T.Nees), C.A. Mey. (Araliaceae), (Fisch) Bunge (Fabaceae), (Oliv.) Diels (Apiaceae), W.T. Aiton (Oleaceae), (Gaertn.) DC. (Plantaginaceae), and (L.) . (Compositae). The aim of this study was to evaluate whether BT can promote hair growth in C57BL/6 mice and to investigate hair coverage, the expression of vascular endothelial growth factor (VEFG), and the numbers of hair follicles in growth phase after oral administration. A total of 12 C57BL/6 mice were divided into two groups: control group and treatment group BT. BT was administered orally as an extract at a volume of 0.6 g/kg. The control group was treated with distilled water. Each group was treated once a day for 12 consecutive days. To observe the expression of VEGF distribution, the number of hair follicles and the hair coverage were examined on days 4, 8, and 12. By comparing the treatment group and control group, we found that VEGF in the BT group on day 8 presented with a higher area percentage than the control group ( value = 0.003). Hair follicle counting results showed that the BT group was significantly higher than the control group on day 8 ( value = 0.031). Furthermore, hair coverage was shown to be significantly increased in the treatment group BT on day 8 ( value = 0.013). Taken together, these results suggest that Chinese medicine (BT) possesses the potential effect of promoting hair growth through VEGF expression. VEGF is considered the most important mediator for the process of angiogenesis involved in hair growth development.
尽管米诺地尔和非那雄胺已被美国食品药品监督管理局（FDA）批准用于治疗脱发，但寻找新的创新型脱发治疗方法很重要，比如从中药中寻找解决方案。一种值得考虑的治疗方法是博托（BT），其主要成分包括[具体植物名称1]（[植物科属1]）、[具体植物名称2]（[植物科属2]）、[具体植物名称3]（[植物科属3]）、[具体植物名称4]（[植物科属4]）、[具体植物名称5]（[植物科属5]）、[具体植物名称6]（[植物科属6]）以及[具体植物名称7]（[植物科属7]）。本研究的目的是评估BT是否能促进C57BL/6小鼠的毛发生长，并研究口服给药后毛发覆盖率、血管内皮生长因子（VEGF）的表达以及生长期毛囊的数量。总共12只C5BL/6小鼠被分为两组：对照组和BT治疗组。BT以提取物形式按0.6 g/kg的剂量口服给药。对照组用蒸馏水治疗。每组连续12天每天治疗一次。为观察VEGF分布的表达情况，在第4天、第8天和第12天检查毛囊数量和毛发覆盖率。通过比较治疗组和对照组，我们发现第8天BT组的VEGF面积百分比高于对照组（P值 = 0.003）。毛囊计数结果显示，第8天BT组显著高于对照组（P值 = 0.031）。此外，第8天BT治疗组的毛发覆盖率显著增加（P值 = 0.013）。综上所述，这些结果表明中药（BT）具有通过VEGF表达促进毛发生长的潜在作用。VEGF被认为是毛发生长发育过程中血管生成最重要的介质。
