Suppr超能文献

绝经期高血压女性的代谢综合征:基于一般实践电子健康记录数据的病例研究。

Metabolic syndrome in hypertensive women in the age of menopause: a case study on data from general practice electronic health records.

机构信息

Department for Internal Medicine, Family Medicine and the History of Medicine, Faculty of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia, Huttlerova 10b, 31 000, Osijek, Croatia.

Department of Cybernetics and Artificial Intelligence, Technical University of Košice, Faculty of Electrical Engineering and Informatics, Letná 9/B, 042 00, Košice, Slovakia.

出版信息

BMC Med Inform Decis Mak. 2018 Apr 2;18(1):24. doi: 10.1186/s12911-018-0601-2.

Abstract

BACKGROUND

There is potential for medical research on the basis of routine data used from general practice electronic health records (GP eHRs), even in areas where there is no common GP research platform. We present a case study on menopausal women with hypertension and metabolic syndrome (MS). The aims were to explore the appropriateness of the standard definition of MS to apply to this specific, narrowly defined population group and to improve recognition of women at high CV risk.

METHODS

We investigated the possible uses offered by available data from GP eHRs, completed with patients interview, in goal of the study, using a combination of methods. For the sample of 202 hypertensive women, 47-59 years old, a data set was performed, consisted of a total number of 62 parameters, 50 parameters used from GP eHRs. It was analysed by using a mixture of methods: analysis of differences, cutoff values, graphical presentations, logistic regression and decision trees.

RESULTS

The age range found to best match the emergency of MS was 51-55 years. Deviations from the definition of MS were identified: a larger cut-off value of the waist circumference measure (89 vs 80 cm) and parameters BMI and total serum cholesterol perform better as components of MS than the standard parameters waist circumference and HDL-cholesterol. The threshold value of BMI at which it is expected that most of hypertensive menopausal women have MS, was found to be 25.5. The other best means for recognision of women with MS include triglycerides above the threshold of 1.7 mmol/L and information on statins use. Prevention of CVD should focus on women with a new onset diabetes and comorbidities of a long-term hypertension with anxiety/depression.

CONCLUSIONS

The added value of this study goes beyond the current paradigm on MS. Results indicate characteristics of MS in a narrowly defined, specific population group. A comprehensive view has been enabled by using heterogenoeus data and a smart combination of various methods for data analysis. The paper shows the feasibility of this research approach in routine practice, to make use of data which would otherwise not be used for research.

摘要

背景

即使在没有通用的全科医生研究平台的地方,基于全科医生电子健康记录(GP eHRs)中使用的常规数据进行医学研究也具有潜力。我们提出了一个关于高血压和代谢综合征(MS)的绝经后妇女的案例研究。目的是探讨标准 MS 定义应用于这个特定的、狭义定义的人群的适宜性,并提高对高心血管风险妇女的认识。

方法

我们使用患者访谈来补充 GP eHRs 中的可用数据,以组合方法研究研究目标的可能用途。对于 202 名年龄在 47-59 岁的高血压女性样本,进行了一个包含 62 个参数的数据集,其中 50 个参数来自 GP eHRs。使用多种方法进行分析:差异分析、临界值、图形表示、逻辑回归和决策树。

结果

发现最符合 MS 发生的年龄范围是 51-55 岁。确定了与 MS 定义的偏差:腰围测量的较大截断值(89 比 80 cm)和 BMI 和总血清胆固醇等参数作为 MS 的组成部分比标准参数腰围和 HDL-胆固醇表现更好。发现绝经后高血压女性中大多数患有 MS 的 BMI 阈值值为 25.5。识别患有 MS 的女性的其他最佳方法包括甘油三酯高于 1.7 mmol/L 的阈值和他汀类药物使用的信息。CVD 的预防应侧重于新发糖尿病和长期高血压伴焦虑/抑郁的女性。

结论

这项研究的附加值超出了目前对 MS 的认识。结果表明,在一个狭义的、特定的人群中,MS 具有特征。通过使用异质数据和各种数据分析方法的智能组合,实现了全面的观点。本文展示了在常规实践中利用原本不会用于研究的数据进行这种研究方法的可行性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6df0/5880083/f1a54e8c0902/12911_2018_601_Fig1_HTML.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验