Poljak Z, Hulin I, Maruscakova L, Mladosievicova B
Pharmazie. 2018 Apr 2;73(4):187-190. doi: 10.1691/ph.2018.7992.
In the physiological view the human cardiomyocytes express receptors of gonadotropin-releasing hormone and follicle-stimulating hormone. The local effects of these hormones in the heart are related also to some interstitial cells, such as endothelial cells with follicle-stimulating hormone receptors and immune cells with gonadotropin-releasing hormone receptors. The administration of androgen deprivation therapy in patients with prostate cancer is associated with increased incidence of cardiovascular complications. It is suggested that negative action of this therapy on cardiovascular system is due to the loss of testosterone but also levels of gonadotropin-releasing hormone and follicle-stimulating hormone are changed by therapy. In this article we review the literature to date with an emphasis on recent investigation focused on potential role of abnormal gonadotropin-releasing hormone and follicle-stimulating hormone levels induced by gonadotropin-releasing hormone agonists on the cardiovascular risk. These facts exacerbate the complexity of specific hormone and cell relationships within heart and vessels. Androgen deprivation therapy reveals the physiological relationships between hormones and specific tissues that are not part of the endocrine system.
从生理学角度来看，人类心肌细胞表达促性腺激素释放激素和促卵泡生成素的受体。这些激素在心脏中的局部作用也与一些间质细胞有关，例如具有促卵泡生成素受体的内皮细胞和具有促性腺激素释放激素受体的免疫细胞。对前列腺癌患者进行雄激素剥夺治疗与心血管并发症发生率增加有关。有人认为，这种治疗对心血管系统的负面作用是由于睾酮的丧失，但治疗也会改变促性腺激素释放激素和促卵泡生成素的水平。在本文中，我们回顾了迄今为止的文献，重点是最近的研究，这些研究聚焦于促性腺激素释放激素激动剂诱导的促性腺激素释放激素和促卵泡生成素水平异常对心血管风险的潜在作用。这些事实加剧了心脏和血管内特定激素与细胞关系的复杂性。雄激素剥夺疗法揭示了激素与不属于内分泌系统的特定组织之间的生理关系。
