Wartman Lukas D
Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2). doi: 10.1101/mcs.a002824. Print 2018 Apr.
Clinicians should soon have the opportunity to use precision oncogenomics to tailor the optimal cancer treatment to a specific patient. Precision oncogenomics will incorporate different sequencing platforms depending on the goal of the sequencing result. For example, the sequencing strategy used in immuno-oncology for the design of a tumor-specific vaccine may be different than that used by oncologists following a patient for clearance of mutations from circulating tumor DNA in the peripheral blood. I will provide a broad overview of several of the ways that precision oncogenomics is likely to influence the field of oncology over the next several years building off the experience at the Genomics Tumor Board at Washington University in St. Louis and a case of small-cell neuroendocrine carcinoma of the endometrium as examples.
临床医生很快将有机会使用精准肿瘤基因组学为特定患者量身定制最佳癌症治疗方案。精准肿瘤基因组学将根据测序结果的目标采用不同的测序平台。例如，免疫肿瘤学中用于设计肿瘤特异性疫苗的测序策略可能与肿瘤学家用于追踪患者外周血中循环肿瘤DNA突变清除情况的测序策略不同。我将以圣路易斯华盛顿大学基因组肿瘤委员会的经验以及一例子宫内膜小细胞神经内分泌癌为例，概述精准肿瘤基因组学在未来几年可能影响肿瘤学领域的几种方式。
