Pisoni Cecilia N, Muñoz Sebastián A, Tamborenea María N, García Mercedes, Curti Ana, Cappuccio Ana, Rillo Oscar, Imamura Patricia M, Schneeberger Emilce, Ballent Marcela, Cousseau Mario L, Velasco Zamora Jorge, Saurit Verónica, Toloza Sergio, Danielsen María C, Bellomio Verónica I, Graf Cesar, Paira Sergio, Cavallasca Javier, Pons Estel Bernardo, Moreno José L C, Díaz Mónica, Alba Paula, Verando Marcela, Tate Guillermo, Mysler Eduardo, Sarano Judith, Civit Emma E, Risueño Fabián, Álvarez Sepúlveda Pablo, Larroude María S, Méndez Marcos F, Conforti Andrea, Sohn Débora
Immunology and Rheumatology Section, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (CEMIC), Ciudad Autónoma de, Buenos Aires, Argentina.
Hospital General de Agudos Juan A. Fernández, Ciudad Autónoma de Buenos Aires, Argentina.
Int J Rheum Dis. 2018 Nov;21(11):2019-2027. doi: 10.1111/1756-185X.13269. Epub 2018 Apr 2.
To study the prevalence and the associated factors of work disability (WD) in systemic lupus erythematosus (SLE) patients.
A sample of 419 SLE patients from an observational cross-sectional multicenter study was included. Sociodemographic features, disease characteristics, comorbidities, quality of life, unhealthy behaviors, and work-related factors were measured in a standardized interview. Work disability was defined by patient self-report of not being able to work because of SLE. To identify variables associated with work disability, two different multivariate regression models using a stepwise backward method were performed.
Prevalence of WD due to SLE was 24.3%. Eighty-nine percent were female and 51% were Caucasians. Mean disease duration was 8.9 ± 7.2 years, and median System Lupus International Collaborating Clinics/American College of Rheumatology damage index SLICC-SDI was 1.5 (range 0-17). In stepwise multivariate logistic regression, living below the poverty line (odds ratio [OR] = 4.65), less than 12 years of education (OR = 2.84), Mestizo ethnicity (OR = 1.94) and SLICC-SDI (OR = 1.25) were predictors of WD. A second model was performed including patient-derived measures; in this model sedentary lifestyle (OR = 2.69) and lower emotional health domain score of the Lupus Quality of Life (LupusQoL) questionnaire (OR = 1.03) were found to be associated to WD and a higher score in LupusQoL physical health domain (OR = 0.93) was protective.
The prevalence of WD in Argentinian SLE patients was 24.3%. WD was associated with ethnic (Mestizo), socioeconomic (poverty) and disease-related factors. Patient-related outcomes such us sedentary lifestyle and poor emotional quality of life were also associated with WD.
研究系统性红斑狼疮（SLE）患者工作残疾（WD）的患病率及相关因素。
纳入一项观察性横断面多中心研究中的419例SLE患者样本。通过标准化访谈测量社会人口学特征、疾病特征、合并症、生活质量、不健康行为及工作相关因素。工作残疾由患者自述因SLE无法工作来定义。为确定与工作残疾相关的变量，采用逐步向后法进行了两种不同的多变量回归模型分析。
因SLE导致的工作残疾患病率为24.3%。89%为女性，51%为白种人。平均病程为8.9±7.2年，系统性红斑狼疮国际协作临床/美国风湿病学会损伤指数（SLICC-SDI）中位数为1.5（范围0 - 17）。在逐步多变量逻辑回归中，生活在贫困线以下（比值比[OR]=4.65）、受教育年限不足12年（OR = 2.84）、混血种族（OR = 1.94）和SLICC-SDI（OR = 1.25）是工作残疾的预测因素。进行了第二个模型分析，纳入患者自我报告的指标；在该模型中，久坐不动的生活方式（OR = 2.69）和狼疮生活质量（LupusQoL）问卷中较低的情绪健康领域得分（OR = 1.03）与工作残疾相关，而LupusQoL身体健康领域较高得分（OR = 0.93）具有保护作用。
阿根廷SLE患者中工作残疾的患病率为24.3%。工作残疾与种族（混血）、社会经济（贫困）和疾病相关因素有关。与患者相关的结果，如久坐不动的生活方式和较差的情绪生活质量也与工作残疾有关。
