Elera-Fitzcarrald Claudia, Alva Magaly, Gamboa-Cardenas Rocío, Mora-Trujillo Claudia S, Zevallos Francisco, García-Poma Augusto, Medina Mariela, Rodriguez-Bellido Zoila, Perich-Campos Risto A, Pastor-Asurza César A, Segami María I, Ugarte-Gil Manuel F
1 Rheumatology Department, 280155 Hospital Guillermo Almenara Irigoyen , EsSalud.
2 School of Medicine, Universidad Científica del Sur.
Lupus. 2018 May;27(6):913-919. doi: 10.1177/0961203317751062. Epub 2018 Jan 4.
Objective In this paper, we aim to define factors associated with health-related quality of life (HRQoL) in Mestizo patients with systemic lupus erythematosus (SLE). Methods We evaluated patients with SLE from Peru's two largest hospitals between October 2012 and July 2015 to ascertain HRQoL. Using a standard protocol, we incorporated demographic characteristics, clinical manifestations and treatment in our analysis. HRQoL was measured with the LupusQoL, disease activity was ascertained with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and damage was appraised with the Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) damage index (SDI). The associations between the LupusQoL and these variables were examined using linear regression models. Model selection was based on backward elimination. Results A total of 277 patients fit the inclusion criterion. Of these, 254 (91.7%) were female, the median (interquartile range, IQR) age at diagnosis was 41.5 (33.8-51.8) years, disease duration was 6.5 (2.7-11.3) years. The HRQoL domains most affected were the following: burden to others, fatigue, and intimate relationships. Through multivariate analysis, we determined that older age at diagnosis, higher disease activity, damage, and immunosuppressive drug use were negatively associated with HRQoL. Further, we found that higher socioeconomic status, disease duration, and antimalarial use were positively associated with HRQoL. Conclusion Age at diagnosis, disease activity, damage, and use of immunosuppressive drugs were negatively associated with HRQoL; high socioeconomic status, disease duration, and use of antimalarials were positively associated with HRQoL.
目的 在本文中，我们旨在确定患有系统性红斑狼疮（SLE）的梅斯蒂索患者中与健康相关生活质量（HRQoL）相关的因素。方法 我们评估了2012年10月至2015年7月期间来自秘鲁两家最大医院的SLE患者，以确定其HRQoL。我们采用标准方案，在分析中纳入了人口统计学特征、临床表现和治疗情况。使用狼疮生活质量量表（LupusQoL）测量HRQoL，用系统性红斑狼疮疾病活动指数（SLEDAI）确定疾病活动度，并用系统性红斑狼疮国际协作临床中心（SLICC）/美国风湿病学会（ACR）损伤指数（SDI）评估损伤情况。使用线性回归模型检验LupusQoL与这些变量之间的关联。模型选择基于向后逐步淘汰法。结果 共有277名患者符合纳入标准。其中，254名（91.7%）为女性，诊断时的中位年龄（四分位间距，IQR）为41.5（33.8 - 51.8）岁，病程为6.5（2.7 - 11.3）年。受影响最大的HRQoL领域如下：对他人的负担、疲劳和亲密关系。通过多变量分析，我们确定诊断时年龄较大、疾病活动度较高、存在损伤以及使用免疫抑制药物与HRQoL呈负相关。此外，我们发现较高的社会经济地位、病程以及使用抗疟药物与HRQoL呈正相关。结论 诊断时年龄、疾病活动度、损伤以及免疫抑制药物的使用与HRQoL呈负相关；高社会经济地位、病程以及抗疟药物的使用与HRQoL呈正相关。
