Department of Prosthodontics and Implantology, King Faisal University, Al-Hofuf, Saudi Arabia.
Department of Restorative Dentistry, Taibah University, Madina Munawwarra, Saudi Arabia.
Curr Pharm Des. 2018;24(10):1130-1137. doi: 10.2174/1381612824666180403114615.
The nature and structural composition of antimicrobial peptides are derived from their innate immune response and they are active against various bacteria, fungi and other microorganisms. The aim of this paper was to pool up the literature on the features of human oral defensins antimicrobial peptides. The defensins showed antimicrobial activity against Gram-positive and Gram-negative bacteria and various fungi and viruses. As with their other properties like antiviral, antifungal and antibacterial, human defensins peptides are thought to have a unique amino acid-based structure with Disulphide Bridge which makes them synthesize chemically or naturally with the help of these bacteria. The data contributing in this study was gathered from the research papers published in English language in the last twenty-five years. This literature mainly elaborates the general and analytical characteristics of antimicrobial peptides in the human oral cavity; focusing on the types, biochemistry, and mechanism of action of defensins with its clinical importance.
抗菌肽的性质和结构组成来源于其先天免疫反应，它们对各种细菌、真菌和其他微生物具有活性。本文旨在综述人类口腔防御素抗菌肽的特征。防御素对革兰氏阳性和革兰氏阴性细菌以及各种真菌和病毒表现出抗菌活性。与抗病毒、抗真菌和抗菌等其他特性一样，人们认为防御素肽具有独特的基于氨基酸的结构，带有二硫键，这使得它们在这些细菌的帮助下可以通过化学或自然的方式合成。本研究的数据来自过去 25 年用英语发表的研究论文。本文主要阐述了人类口腔中抗菌肽的一般和分析特征；重点介绍了防御素的类型、生化和作用机制及其临床意义。
