Axial modification inhibited H-aggregation of phthalocyanines in polymeric micelles for enhanced PDT efficacy.
作者信息
Jing Chen, Wang Ruolin, Ou Hanlin, Li Ang, An Yingli, Guo Shutao, Shi Linqi
机构信息
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin 300071, P. R. China.
出版信息
Chem Commun (Camb). 2018 Apr 17;54(32):3985-3988. doi: 10.1039/c7cc09954a.
Axial modified phthalocyanine (BtPc), aiming at avoiding H-aggregation and utilizing long wavelength light, was designed and synthesized. With the aid of polymer nanotechnology, BtPc loaded polymeric micelles with strong singlet oxygen generating ability and enhanced photodynamic therapy efficiency were developed. Optical characterizations and in vitro evaluations proved that the BtPc loaded polymeric micelles hold great potential for photodynamic therapy.
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