School of Environmental Science and Engineering, Kochi University of Technology, Tosayamada, Kami, Kochi 782-8502, Japan.
Org Biomol Chem. 2018 Apr 18;16(15):2768-2775. doi: 10.1039/c8ob00408k.
A highly efficient one-pot synthesis of β,β-dihalo-β-nitroethyl alkyl ethers is achieved by the treatment of nitroalkenes with alcohols and N-halosuccinimides in the presence of sodium hydride. The notable advantages of this protocol are that it involves simple experimental manipulations and tolerates a wide range of functional groups. Further transformations of the obtained ethers, such as allylation and conversion to β,β-dihalogenated vinyl ethers, are also investigated.
通过在氢化钠存在下，用醇和 N-卤代琥珀酰亚胺处理硝烯，可以高效一锅合成β，β-二卤代-β-硝基乙基烷基醚。该方案的显著优点是实验操作简单，并且可以容忍广泛的官能团。还研究了获得的醚的进一步转化，如烯丙基化和转化为β，β-二卤代乙烯基醚。
