CAS Key Laboratory of Soft Matter Chemistry, and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
J Org Chem. 2012 Nov 2;77(21):9504-9. doi: 10.1021/jo301964m. Epub 2012 Oct 3.
A palladium-catalyzed ortho-alkoxylation of anilides with both primary and secondary alcohols via ligand-directed C-H activation has been explored. This alkoxylation promoted by catalytic methanesulfonic acid proceeds well at room temperature in most cases and affords aryl alkyl ethers in moderate to good yields.
钯催化的酰胺与伯醇和仲醇的邻位烷氧基化反应通过配体导向的 C-H 活化得到了探索。在大多数情况下，这种由催化硫酸二甲酯促进的烷氧基化反应在室温下进行得很好，并以中等至良好的收率得到芳基烷基醚。
