Institute of Biological Psychology, Technische Universität Dresden, Dresden, Germany.
Institute of Clinical Psychology and Psychotherapy, Behavioral Epidemiology, Center for Clinical Epidemiology and Longitudinal Studies, Technische Universität Dresden, Dresden, Germany.
Int J Methods Psychiatr Res. 2018 Jun;27(2):e1613. doi: 10.1002/mpr.1613. Epub 2018 Apr 3.
The Dresden Burnout Study (DBS) is a 12-year longitudinal cohort study that aims to provide a description of the burnout syndrome on the basis of time and symptom criteria with a special focus on the search for biomarkers. Biological and psychosocial approaches are applied to examine the long-term course and consequences of burnout within a population-based German-speaking sample aged 18 to 68 years.
Demographics and psychosocial data are generated by online assessments, including demographics and questionnaires on burnout, burnout-related constructs, work-environment, and health-related factors. The lab-based biomarker assessment includes endocrine, physiological, immunological, and epigenetic markers obtained from blood and hair samples. In addition, heart rate variability is also measured repeatedly. Within the first 2 years, the DBS collected psychosocial data from over 7,600 participants with biological data obtained from more than 800 individuals. During the following 10 years, detailed assessments of biomarkers and psychosocial factors will be collected in annual study waves.
Results will be generated during the following decade.
The findings of the DBS are expected to pave the road for an in-depth biopsychosocial characterization of burnout and to give insight into the long-term course and potential mental and physical health consequences of the burnout syndrome.
德累斯顿 burnout 研究（DBS）是一项为期 12 年的纵向队列研究，旨在根据时间和症状标准对 burnout 综合征进行描述，特别关注寻找生物标志物。该研究采用生物学和社会心理学方法，在一个年龄在 18 至 68 岁之间的基于人群的德语样本中，检查 burnout 的长期病程和后果。
人口统计学和社会心理数据通过在线评估生成，包括人口统计学和关于 burnout、与 burnout 相关的结构、工作环境和与健康相关的因素的问卷。基于实验室的生物标志物评估包括内分泌、生理、免疫和表观遗传标记，这些标记来自血液和头发样本。此外，还多次测量心率变异性。在最初的 2 年内，DBS 从超过 7600 名参与者那里收集了社会心理数据，从 800 多名参与者那里获得了生物数据。在接下来的 10 年中，将在年度研究波中对生物标志物和社会心理因素进行详细评估。
研究结果将在未来十年内得出。
DBS 的研究结果有望为 burnout 的深入生物心理特征描述铺平道路，并深入了解 burnout 综合征的长期病程和潜在的心理和身体健康后果。
