中度低氧血症对正常男性心房利钠因子和精氨酸加压素的影响。

Effect of moderate hypoxemia on atrial natriuretic factor and arginine vasopressin in normal man.

作者信息

du Souich P, Saunier C, Hartemann D, Sautegeau A, Ong H, Larose P, Babini R

机构信息

INSERM U. 14, Nancy, France.

出版信息

Biochem Biophys Res Commun. 1987 Nov 13;148(3):906-12. doi: 10.1016/s0006-291x(87)80218-8.

DOI:10.1016/s0006-291x(87)80218-8

PMID:2961334

Abstract

The object of this study was to assess the effect of moderate acute hypoxemia on plasma concentrations of atrial natriuretic factor (ANF), arginine vasopressin (AVP), plasma renin activity (PRA) and urinary excretion of prostaglandin E2 (UPGE2V). Eight volunteers were exposed for 2 hours to a gas mixture containing 10% O2, 4.5% CO2 and 85.5% N2. Hypoxia increased diastolic blood pressure and free water clearance. Hypoxia did not change the AVP, PRA or UPG2V, although increased ANF from 17.7 +/- 3.4 pg/mL to 27.2 +/- 1.7 pg/mL (p less than 0.005) at 120 minutes. ANF changes were closely associated with the rise in blood pressure.

摘要

本研究的目的是评估中度急性低氧血症对心房利钠因子（ANF）、精氨酸加压素（AVP）、血浆肾素活性（PRA）和前列腺素E2尿排泄量（UPGE2V）的影响。八名志愿者暴露于含有10%氧气、4.5%二氧化碳和85.5%氮气的混合气体中2小时。低氧血症会升高舒张压和自由水清除率。低氧血症并未改变AVP、PRA或UPG2V，尽管在120分钟时ANF从17.7±3.4 pg/mL升高至27.2±1.7 pg/mL（p<0.005）。ANF的变化与血压升高密切相关。