Martin J, Neill R S
Department of Anaesthesia, Ninewells Hospital and Medical School, Dundee.
Br J Anaesth. 1987 Nov;59(11):1425-30. doi: 10.1093/bja/59.11.1425.
Following local anaesthesia of the lower abdominal wall, in patients undergoing laparoscopic sterilization (n = 16), using 0.5% plain bupivacaine 40 ml (n = 8), or 0.5% bupivacaine with 1:200000 adrenaline (n = 8), venous plasma (total) bupivacaine concentrations were measured (gas-liquid chromatography) at intervals up to 2 h after the local anaesthetic was injected. Mean peak plasma venous concentration achieved following 0.5% plain bupivacaine was 2.23 +/- 0.24 micrograms ml-1 (mean +/- SEM), while the mean peak concentration following 0.5% bupivacaine with adrenaline was 0.98 +/- 0.10 micrograms ml-1 (mean +/- SEM). At all sampling times up to and including 45 min after the injection of local anaesthetic, the plasma concentrations were significantly less in the bupivacaine with adrenaline group when compared with the group in whom a plain solution was used.
在下腹部壁局部麻醉后，对接受腹腔镜绝育手术的患者（n = 16）进行研究，其中8例使用40毫升0.5%的布比卡因原液，8例使用含1:200000肾上腺素的0.5%布比卡因。在注射局部麻醉剂后长达2小时的时间内，每隔一段时间测量静脉血浆（总）布比卡因浓度（采用气液色谱法）。使用0.5%布比卡因原液后达到的平均血浆静脉峰值浓度为2.23±0.24微克/毫升（平均值±标准误），而使用含肾上腺素的0.5%布比卡因后的平均峰值浓度为0.98±0.10微克/毫升（平均值±标准误）。在注射局部麻醉剂后直至包括45分钟在内的所有采样时间，与使用布比卡因原液组相比，含肾上腺素的布比卡因组的血浆浓度显著更低。
