Chung Dawn, Lee Yoo Jin, Jo Mi Hyun, Park Hyun Jong, Lim Ga Won, Cho Hanbyoul, Nam Eun Ji, Kim Sang Wun, Kim Jae Hoon, Kim Young Tae, Kim Sunghoon
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
Obstet Gynecol Sci. 2013 Mar;56(2):93-101. doi: 10.5468/OGS.2013.56.2.93. Epub 2013 Mar 12.
The goal of this study was to compare postoperative surgical site pain in gynecologic cancer patients who underwent elective extended lower midline laparotomy and managed their pain with either the ON-Q pain management system (surgical incision site pain relief system, ON-Q pump) or an intravenous patient-controlled analgesia pump (IV PCA).
Twenty gynecologic cancer patients who underwent elective extended lower midline laparotomy were divided into two groups. One group received a 72-hour continuous wound perfusion of the local anesthetic ropivacaine (0.5%, study group) into the supraperitoneal layer of the abdominal incision through the ON-Q pump. The other group received intravenous infusion pump of patient-controlled analgesia (fentanyl citrate 20 mg/mL · kg+ondansetron hydrochloride 16 mg/8 mL+normal saline). Postoperative pain was assessed immediately and at 6, 24, 48, 72, and 96 hours after surgery using the visual analogue scale.
Postoperative surgical site pain scores at 24, 48, and 72 hours after surgery were lower in the ON-Q group than the IV PCA group. Pain scores at 24 hours and 48 hours after surgery were significantly different between the two groups (P=0.023, P<0.001). Overall painkiller administration was higher in the ON-Q group but this difference was not statistically significant (5.1 vs. 4.3, P=0.481).
This study revealed that the ON-Q pain management system is a more effective approach than IV PCA for acute postoperative surgical site pain relief after extended lower midline laparotomy in gynecologic cancer patients.
本研究的目的是比较接受选择性扩大下腹部正中剖腹手术的妇科癌症患者术后手术部位疼痛情况,这些患者使用ON-Q疼痛管理系统(手术切口部位疼痛缓解系统,ON-Q泵)或静脉自控镇痛泵(IV PCA)进行疼痛管理。
20例接受选择性扩大下腹部正中剖腹手术的妇科癌症患者被分为两组。一组通过ON-Q泵将局部麻醉药罗哌卡因(0.5%,研究组)持续72小时灌注到腹部切口的腹膜上层。另一组接受静脉自控镇痛输液泵(枸橼酸芬太尼20mg/mL·kg+盐酸昂丹司琼16mg/8mL+生理盐水)。术后立即以及术后6、24、48、72和96小时使用视觉模拟量表评估疼痛情况。
ON-Q组术后24、48和72小时的手术部位疼痛评分低于IV PCA组。两组术后24小时和48小时的疼痛评分有显著差异(P=0.023,P<0.001)。ON-Q组的总体止痛药使用量较高,但差异无统计学意义(5.1对4.3,P=0.481)。
本研究表明,对于妇科癌症患者扩大下腹部正中剖腹手术后的急性手术部位疼痛缓解,ON-Q疼痛管理系统比IV PCA更有效。