Norwegian Veterinary Institute, Pb 750 Sentrum, 0106, Oslo, Norway.
Norwegian Veterinary Institute, Pb 750 Sentrum, 0106, Oslo, Norway.
Vet Microbiol. 2018 Apr;217:25-31. doi: 10.1016/j.vetmic.2018.02.022. Epub 2018 Feb 23.
The aim of this study was to describe and compare the occurrence of quinolone resistant Escherichia coli (QREC) in various animal species in relation to human population density. Data from the Norwegian monitoring programme for antimicrobial resistance in feed, food and animals from 2006 to 2016 was compiled and analysed. In total, 4568 E. coli isolates were included in this study. The isolates originated from broilers, layers, cattle, turkeys, dogs, wild birds, red foxes, reindeer, sheep, horses and pigs. Data regarding the geographical location of sampling was obtained for 4050 of these isolates and used to categorize the isolates depending on the human population density of the area. In total, 1.4% of the isolates were categorized as quinolone resistant. Compared to most European countries, there was an overall low occurrence of QREC in various animal species in Norway, though with an interspecies variation with the highest occurrence in broilers and wild birds (p < 0.05). Human population density was not associated with the occurrence of QREC. Since fluoroquinolones are not used prophylactically and in almost negligent amounts in various species in Norway, the interspecies variation in the occurrence of QREC suggests that other factors than fluoroquinolone use may be important in the development of QREC.
本研究旨在描述和比较与人类人口密度相关的各种动物物种中喹诺酮耐药大肠杆菌（QREC）的发生情况。我们编译和分析了 2006 年至 2016 年来自挪威饲料、食品和动物中抗菌药物耐药性监测计划的数据。本研究共纳入了 4568 株大肠杆菌分离株。这些分离株来自肉鸡、蛋鸡、牛、火鸡、狗、野生鸟类、赤狐、驯鹿、绵羊、马和猪。其中 4050 株分离株获得了采样地理位置的数据，并根据该地区的人类人口密度对这些分离株进行了分类。总的来说，1.4%的分离株被归类为喹诺酮耐药。与大多数欧洲国家相比，挪威各种动物物种中 QREC 的总体发生率较低，但在肉鸡和野生鸟类中存在物种间差异（p < 0.05）。人类人口密度与 QREC 的发生无关。由于氟喹诺酮类药物在挪威的各种动物中并未预防性使用，且使用量几乎可以忽略不计，因此 QREC 发生的种间差异表明，除了氟喹诺酮类药物的使用外，其他因素可能对 QREC 的发展也很重要。
