Kaspersen Håkon, Urdahl Anne Margrete, Grøntvedt Carl Andreas, Gulliksen Stine Margrethe, Tesfamichael Bereket, Slettemeås Jannice Schau, Norström Madelaine, Sekse Camilla
Norwegian Veterinary Institute, P.O. Box 750 Sentrum, 0106 Oslo, Norway.
Animalia, P.O. Box 396 Økern, 0513 Oslo, Norway.
Antibiotics (Basel). 2020 Dec 15;9(12):910. doi: 10.3390/antibiotics9120910.
Norway has a favourable situation with regard to health status and antimicrobial usage in the pig production sector. However, one of the major disease-causing agents in the commercial pig population is (APP). In some herds, APP eradication has been performed by using enrofloxacin in combination with a partial herd depopulation. The aim of this study was to investigate the long-term effects of a single treatment event with enrofloxacin on the occurrence of quinolone resistant (QREC). The study was designed as a retrospective case/control study, where the herds were selected based on treatment history. Faecal samples were taken from sows, gilts, fattening pigs and weaners for all herds where available. A semi-quantitative culturing method was used to identify the relative quantity of QREC in the faecal samples. A significant difference in overall occurrence and relative quantity of QREC was identified between the case and control herds, as well as between each animal age group within the case/control groups. The results indicate that a single treatment event with enrofloxacin significantly increased the occurrence of QREC in the herd, even years after treatment and with no subsequent exposure to quinolones.
挪威在生猪生产部门的健康状况和抗菌药物使用方面具有有利形势。然而，商品猪群中的主要致病因子之一是（APP）。在一些猪群中，已通过使用恩诺沙星结合部分猪群扑杀来根除APP。本研究的目的是调查单次使用恩诺沙星治疗对喹诺酮耐药菌（QREC）发生的长期影响。该研究设计为一项回顾性病例/对照研究，根据治疗史选择猪群。在所有可获取样本的猪群中，从母猪、后备母猪、育肥猪和断奶仔猪采集粪便样本。采用半定量培养方法确定粪便样本中QREC的相对数量。病例组和对照组猪群之间以及病例/对照组内各动物年龄组之间，QREC的总体发生率和相对数量均存在显著差异。结果表明，即使在治疗数年之后且后续未再接触喹诺酮类药物的情况下，单次使用恩诺沙星治疗也会显著增加猪群中QREC的发生率。
