Danesin Cathy, Soula Cathy
Centre de Biologie du Développement (CBD) CNRS/UPS, Centre de Biologie Intégrative (CBI), Université de Toulouse, 31520 Toulouse, France.
J Dev Biol. 2017 Apr 12;5(2):4. doi: 10.3390/jdb5020004.
A substantial amount of data has highlighted the crucial influence of Shh signalling on the generation of diverse classes of neurons and glial cells throughout the developing central nervous system. A critical step leading to this diversity is the establishment of distinct neural progenitor cell domains during the process of pattern formation. The forming spinal cord, in particular, has served as an excellent model to unravel how progenitor cells respond to Shh to produce the appropriate pattern. In recent years, considerable advances have been made in our understanding of important parameters that control the temporal and spatial interpretation of the morphogen signal at the level of Shh-receiving progenitor cells. Although less studied, the identity and position of Shh source cells also undergo significant changes over time, raising the question of how moving the Shh source contributes to cell diversification in response to the morphogen. Here, we focus on the dynamics of Shh-producing cells and discuss specific roles for these time-variant Shh sources with regard to the temporal events occurring in the receiving field.
大量数据突出了 Sonic Hedgehog（Shh）信号通路在整个发育中的中枢神经系统中对各类神经元和神经胶质细胞生成的关键影响。导致这种多样性的关键步骤是在模式形成过程中建立不同的神经祖细胞区域。特别是正在形成的脊髓，已成为揭示祖细胞如何响应 Shh 以产生适当模式的绝佳模型。近年来，我们在理解控制 Shh 信号接收祖细胞水平上形态发生素信号的时间和空间解读的重要参数方面取得了相当大的进展。虽然研究较少，但 Shh 源细胞的身份和位置也会随时间发生显著变化，这就提出了一个问题，即 Shh 源细胞的移动如何响应形态发生素促进细胞多样化。在这里，我们关注产生 Shh 的细胞的动态，并讨论这些随时间变化的 Shh 源在接收区域发生的时间事件方面的特定作用。
