Bushman Wade
Department of Urology, Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53705, USA.
J Dev Biol. 2016 Oct 19;4(4):30. doi: 10.3390/jdb4040030.
The prostate is a developmental model system study of prostate growth regulation. Historically the research focus was on androgen regulation of development and growth and instructive interactions between the mesenchyme and epithelium. The study of Hh signaling in prostate development revealed important roles in ductal morphogenesis and in epithelial growth regulation that appear to be recapitulated in prostate cancer. This overview of Hh signaling in the prostate will address the well-described role of paracrine signaling prostate development as well as new evidence suggesting a role for autocrine signaling, the role of Hh signaling in prostate regeneration and reiterative activities in prostate cancer.
前列腺是前列腺生长调节的一个发育模型系统研究。从历史上看，研究重点在于雄激素对发育和生长的调节以及间充质与上皮之间的诱导性相互作用。对前列腺发育中Hh信号的研究揭示了其在导管形态发生和上皮生长调节中的重要作用，这些作用似乎在前列腺癌中重现。本文对前列腺中Hh信号的概述将阐述旁分泌信号在前列腺发育中已明确的作用，以及提示自分泌信号作用的新证据、Hh信号在前列腺再生中的作用和在前列腺癌中的重复活动。
