Doctorado en Biociencias, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos, Jalisco, Mexico.
Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Front Endocrinol (Lausanne). 2024 Feb 2;15:1333284. doi: 10.3389/fendo.2024.1333284. eCollection 2024.
Prostate cancer (PCa) is the most prevalent cause of death in the male population worldwide. The G Protein-Coupled Estrogen Receptor (GPER) has been gaining relevance in the development of PCa. Hedgehog (Hh) pathway activation is associated with aggressiveness, metastasis, and relapse in PCa patients. To date, no studies have evaluated the crosstalk between the GPER and the Hh pathway along different group grades in PCa. We conducted an analysis of paraffin-embedded tissues derived from patients with different prognostic grade of PCa using immunohistochemistry. Expression and correlation between GPER and glioma associated oncogene homologue (GLI) transcriptional factors in the parenchyma and stroma of PCa tumors were evaluated. Our results indicate that GPER is highly expressed in the nucleus and increases with higher grade groups. Additionally, GPER's expression correlates with pGLI3 nuclear expression across different grade groups in PCa tissues; however, whether the receptor induces the activation of GLI transcriptional factors, or the latter modulate the expression of GPER is yet to be discovered, as well as the functional consequence of this correlation.
前列腺癌（PCa）是全球男性人群中最常见的死亡原因。G 蛋白偶联雌激素受体（GPER）在前列腺癌的发展中变得越来越重要。Hedgehog（Hh）通路的激活与前列腺癌患者的侵袭性、转移和复发有关。迄今为止，尚无研究评估 GPER 与 Hh 通路在不同分组等级的前列腺癌中的相互作用。我们使用免疫组织化学分析了来自不同预后等级前列腺癌患者的石蜡包埋组织。评估了 GPER 和胶质瘤相关致癌基因同系物（GLI）转录因子在前列腺癌肿瘤实质和基质中的表达和相关性。我们的结果表明，GPER 在细胞核中高度表达，并随着分级组的增加而增加。此外，在不同分级组的前列腺癌组织中，GPER 的表达与 pGLI3 核表达相关；然而，受体是否诱导 GLI 转录因子的激活，或者后者是否调节 GPER 的表达，以及这种相关性的功能后果，仍有待发现。
