毛果芸香碱诱导的大鼠无目的咀嚼行为依赖于完整的5-羟色胺中枢储备。
Pilocarpine-induced purposeless chewing behaviour in rats is dependent on intact central stores of 5-HT.
作者信息
Stewart B, Rose S, Jenner P, Marsden C D
机构信息
MRC Movement Disorders Research Group, University Department of Neurology, London, U.K.
出版信息
Eur J Pharmacol. 1987 Oct 6;142(1):173-6. doi: 10.1016/0014-2999(87)90671-6.
PMID:2961579
Abstract
Pilocarpine-induced purposeless chewing behaviour in rats was partially antagonised by pretreatment with reserpine, tetrabenazine or p-chlorophenylalanine (PCPA). In contrast, pretreatment with alpha-methyl-p-tyrosine (AMPT) had no effect on pilocarpine-induced chewing. These data suggest that enhancement of purposeless chewing by pilocarpine is dependent, in part, on intact central stores of 5-HT.
摘要
用利血平、丁苯那嗪或对氯苯丙氨酸（PCPA）预处理可部分拮抗毛果芸香碱诱导的大鼠无目的咀嚼行为。相比之下，用α-甲基-对酪氨酸（AMPT）预处理对毛果芸香碱诱导的咀嚼没有影响。这些数据表明，毛果芸香碱增强无目的咀嚼部分依赖于完整的5-羟色胺中枢储存。
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