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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Williams S P, Newton R P, Brown E G

Department of Biochemistry, University College of Swansea, U.K.

Int J Biochem. 1987;19(9):879-84. doi: 10.1016/0020-711x(87)90249-7.

Rat liver nucleotides were separated on a weak anion-exchange HPLC column. The characteristic nucleotide profile could be modified by treatment of the rats with ethanol, at both acute and chronic dosages, by fructose and by nicotinamide. 2. The major effect observed after ethanol administration was a decrease in the concentration of ATP with increases in the concentrations of AMP and other nucleotide monophosphates. 3. These changes gradually reverted to normal values over a 30 min period. 4. Ingestion of 1 or 5% ethanol for 4 weeks caused similar changes in the nucleotide profile of liver. 5. Fructose administration caused a dramatic but reversible decrease in the size of the entire nucleotide pool. 6. Rats given daily injections of nicotinamide exhibited greatly elevated concentrations of liver NAD+, whereas the other pyridine nucleotides were relatively unaffected. 7. The results are discussed in relation to the known effect on metabolism of the compounds tested.

大鼠肝脏核苷酸在弱阴离子交换高效液相色谱柱上进行分离。通过给大鼠急性和慢性剂量的乙醇、果糖和烟酰胺处理，可改变特征性核苷酸谱。2. 乙醇给药后观察到的主要效应是ATP浓度降低，同时AMP和其他核苷酸单磷酸浓度增加。3. 这些变化在30分钟内逐渐恢复到正常值。4. 摄入1%或5%乙醇4周会导致肝脏核苷酸谱发生类似变化。5. 给予果糖会使整个核苷酸池的大小显著但可逆地减少。6. 每天注射烟酰胺的大鼠肝脏NAD+浓度大幅升高，而其他吡啶核苷酸相对未受影响。7. 结合所测试化合物对代谢的已知影响对结果进行了讨论。

Williams S P, Newton R P, Brown E G

Department of Biochemistry, University College of Swansea, U.K.

Int J Biochem. 1987;19(9):879-84. doi: 10.1016/0020-711x(87)90249-7.

Rat liver nucleotides were separated on a weak anion-exchange HPLC column. The characteristic nucleotide profile could be modified by treatment of the rats with ethanol, at both acute and chronic dosages, by fructose and by nicotinamide. 2. The major effect observed after ethanol administration was a decrease in the concentration of ATP with increases in the concentrations of AMP and other nucleotide monophosphates. 3. These changes gradually reverted to normal values over a 30 min period. 4. Ingestion of 1 or 5% ethanol for 4 weeks caused similar changes in the nucleotide profile of liver. 5. Fructose administration caused a dramatic but reversible decrease in the size of the entire nucleotide pool. 6. Rats given daily injections of nicotinamide exhibited greatly elevated concentrations of liver NAD+, whereas the other pyridine nucleotides were relatively unaffected. 7. The results are discussed in relation to the known effect on metabolism of the compounds tested.

大鼠肝脏核苷酸在弱阴离子交换高效液相色谱柱上进行分离。通过给大鼠急性和慢性剂量的乙醇、果糖和烟酰胺处理，可改变特征性核苷酸谱。2. 乙醇给药后观察到的主要效应是ATP浓度降低，同时AMP和其他核苷酸单磷酸浓度增加。3. 这些变化在30分钟内逐渐恢复到正常值。4. 摄入1%或5%乙醇4周会导致肝脏核苷酸谱发生类似变化。5. 给予果糖会使整个核苷酸池的大小显著但可逆地减少。6. 每天注射烟酰胺的大鼠肝脏NAD+浓度大幅升高，而其他吡啶核苷酸相对未受影响。7. 结合所测试化合物对代谢的已知影响对结果进行了讨论。