Disciplina de Urologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil.
Int Braz J Urol. 2018 May-Jun;44(3):536-542. doi: 10.1590/S1677-5538.IBJU.2017.0243.
To evaluate urodynamic alterations after sub-urethral sling surgery (SSU) in patients with post-prostatectomy urinary incontinence (PPUI).
We evaluated data of 22 patients submitted to radical prostatectomy (RP) or transurethral resection of prostate (TURP) that presented post-surgical urinary incontinence and were treated with SSU implant in a pilot study previously performed in our institution.
Those patients with PPUI were evaluated by urodynamic exam (UD) before and after surgery, and the parameters were compared, including uroflow, cystometry and micturition study. Exclusion criteria included patients without pre-operatory urodynamic study, those with urethral stenosis, those not healed of prostate cancer, patients without clinical conditions to be submitted to urodynamic study and those with severe neurological diseases or that refused to sign the consent form. Results were analyzed statistically by Fisher, Wilcoxon or Mann-Whitney tests.
During free uroflow, none parameters showed any statistical significant differences. During cystometry, there were also no statistical differences and the same was observed at pressure versus flow study; the exception was at maximal flow detrusor pressure (PdetQmax), that was lower at post-operatory (p=0.028). In relation to the presence of urinary dysfunctions associated to PPUI, we observed a significant reduction of detrusor overactivity (p=0.035) in relation to pre-operatory period.
SSU surgery significantly reduced detrusor overactivity and PdetQMax; however, there were no alterations of other evaluated urodynamic parameters.
评估尿道下悬吊术(SSU)治疗前列腺切除术后尿失禁(PPUI)患者的尿动力学改变。
我们评估了 22 例接受根治性前列腺切除术(RP)或经尿道前列腺切除术(TURP)的患者的数据,这些患者在手术后出现尿失禁,并在我们机构进行的一项初步研究中接受了 SSU 植入治疗。
这些患有 PPUI 的患者在手术前后均接受尿动力学检查(UD),并比较了参数,包括尿流率、膀胱测压和排尿研究。排除标准包括无术前尿动力学研究的患者、尿道狭窄的患者、前列腺癌未治愈的患者、无尿动力学研究条件的患者和严重神经疾病的患者或拒绝签署同意书的患者。结果采用 Fisher、Wilcoxon 或 Mann-Whitney 检验进行统计学分析。
在自由尿流期间,没有任何参数显示出统计学上的显著差异。在膀胱测压期间,也没有统计学差异,压力与流量研究也是如此;唯一的例外是最大逼尿肌压力时的尿流率(PdetQmax),术后较低(p=0.028)。在与 PPUI 相关的尿功能障碍方面,我们观察到逼尿肌过度活动(p=0.035)显著减少。
SSU 手术显著降低了逼尿肌过度活动和 PdetQMax;然而,其他评估的尿动力学参数没有改变。