Institute of Transformative Bio-Molecules (WPI-ITbM) , Nagoya University , Chikusa , Nagoya 464-8602 , Japan.
Graduate School of Science , Nagoya University , Chikusa , Nagoya 464-8602 , Japan.
Org Lett. 2018 Apr 20;20(8):2428-2432. doi: 10.1021/acs.orglett.8b00775. Epub 2018 Apr 4.
The first palladium-catalyzed esterification of carboxylic acids with aryl iodides is described. A palladium-based catalytic system consisting of IBn (1,3-bis((pentafluorophenyl)methyl)imidazole-2-ylidene) ligand was found to significantly accelerate the aryl-O bond-forming esterification reaction. A series of aryl iodides and carboxylic acids undergoes a palladium-catalyzed coupling reaction to provide the corresponding aryl esters in moderate to good yields. In addition, sterically hindered aryl iodides and carboxylic acids were well-tolerated yielding the corresponding aryl esters.
本文描述了首例钯催化的羧酸与芳基碘代物的酯化反应。研究发现，一种基于钯的催化体系，由 IBn（1,3-双((五氟苯基)甲基)咪唑-2-亚基）配体组成，可显著加速芳基-O 键形成的酯化反应。一系列芳基碘化物和羧酸在钯催化下发生偶联反应，以中等至良好的收率得到相应的芳基酯。此外，空间位阻较大的芳基碘化物和羧酸也能耐受反应，生成相应的芳基酯。
