Costa Karla Cristina Malta, Ciampo Luiz Antonio Del, Silva Patrícia Silveira, Lima Jailson Costa, Martins Wellington de Paula, Nogueira de Almeida Carlos Alberto
Departamento de Medicina, Universidade Federal de São Carlos, São Carlos, SP, Brazil.
Rev Paul Pediatr. 2018 Apr-Jun;36(2):171-175. doi: 10.1590/1984-0462/;2018;36;2;00016. Epub 2018 Mar 29.
To evaluate whether the obesity alters ultrasonographical markers of metabolic and cardiovascular disease risk in children.
A cross-sectional study evaluated 80 children aged between 6 and 10 years, comparing 40 obese with 40 normal children. The following parameters were assessed: weight; height; body mass index; arterial blood pressure; body fat; basal metabolic rate; HDL-cholesterol, LDL-cholesterol and total cholesterol; fasting insulin and glucose; quantitative insulin sensitivity check index (QUICKI); homeostasis model of assessment - insulin resistance (HOMA-IR); basal diameter of the brachial artery; brachial artery flow mediated dilation (FMD) and of pulsatility index change (PI-C).
Significant differences were observed between obese vs. non-obese children: systolic blood pressure (97.7±8.4 vs. 89.0±5.8 mmHg; p<0.01), diastolic blood pressure (64.3±7.9 vs. 52.9±5.1 mmHg; p<0.01), proportion of body fat (45.1±5.9 vs. 21.3±6.0%; p<0.01), basal metabolic rate (1216.1±102.1 vs. 1072.9±66.4 Kcal; p<0.01), total cholesterol (164.7±25.2 vs. 153.4±15.8 mg/dL; p=0.03), fasting insulin (7.1±5.2 vs. 2.8±1.8 pIU/mL; p<0.01), HOMA-IR (1.5±1.1 vs. 0.6±0.4; p<0.01), basal diameter of the brachial artery (2.5±0.3 vs. 2.1±0.3 mm; p<0.01); PI-C (-15.5±27.2 vs. -31.9±15.5%; p<0.01), decreased QUICKI (0.4±0.05 vs. 0.4±0.03; p<0.01), and FMD (6.6±3.2 vs. 15.6±7.3%; p<0.01).
Obesity worsens ultrasonographical and laboratorial markers of metabolic and cardiovascular disease risk in children.
评估肥胖是否会改变儿童代谢和心血管疾病风险的超声检查指标。
一项横断面研究对80名6至10岁的儿童进行了评估，将40名肥胖儿童与40名正常儿童进行比较。评估了以下参数：体重；身高；体重指数；动脉血压；体脂；基础代谢率；高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和总胆固醇；空腹胰岛素和血糖；定量胰岛素敏感性检查指数（QUICKI）；稳态模型评估-胰岛素抵抗（HOMA-IR）；肱动脉基础直径；肱动脉血流介导的舒张功能（FMD）和搏动指数变化（PI-C）。
肥胖儿童与非肥胖儿童之间观察到显著差异：收缩压（97.7±8.4 vs. 89.0±5.8 mmHg；p<0.01）、舒张压（64.3±7.9 vs. 52.9±5.1 mmHg；p<0.01）、体脂比例（45.1±5.9 vs. 21.3±6.0%；p<0.01）、基础代谢率（1216.1±102.1 vs. 1072.9±66.4千卡；p<0.01）、总胆固醇（164.7±25.2 vs. 153.4±15.8 mg/dL；p=0.03）、空腹胰岛素（7.1±5.2 vs. 2.8±1.8 pIU/mL；p<0.01）、HOMA-IR（1.5±1.1 vs. 0.6±0.4；p<0.01）、肱动脉基础直径（2.5±0.3 vs. 2.1±0.3 mm；p<0.01）；PI-C（-15.5±27.2 vs. -31.9±15.5%；p<0.01）、QUICKI降低（0.4±0.05 vs. 0.4±0.03；p<0.01）和FMD（6.6±3.2 vs. 15.6±7.3%；p<0.01）。
肥胖会使儿童代谢和心血管疾病风险的超声检查及实验室指标恶化。
