Nestler J E, Barlascini C O, Clore J N, Blackard W G
Division of Endocrinology and Metabolism, Medical College of Virginia/Virginia Commonwealth University, Richmond 23298.
J Clin Endocrinol Metab. 1988 Jan;66(1):57-61. doi: 10.1210/jcem-66-1-57.
To assess the effects of dehydroepiandrosterone (DHEA) on body fat mass, serum lipid levels, and tissue sensitivity to insulin, five normal men were given placebo and five normal men were given oral DHEA [1600 mg/day (554.7 mmol/day)] for 28 days in a randomized, double blind study. In the DHEA group serum DHEA-S levels rose 2.5- to 3.5-fold, and mean (+/- SEM) serum androstenedione rose from 4.3 +/- 0.6 to 8.6 +/- 1.2 nmol/L (P less than 0.004, by paired t test), but serum total testosterone, free testosterone, sex hormone-binding globulin, estradiol, and estrone levels did not change. In the DHEA group the mean percent body fat decreased by 31%, with no change in weight. This suggests that the reduction in fat mass was coupled with an increase in muscle mass. DHEA administration also resulted in a fall in mean serum total cholesterol concentration (4.82 +/- 0.21 vs. 4.48 +/- 0.29 nmol/L; P less than 0.05), which was due almost entirely to a fall of 7.5% in mean serum low density lipoprotein cholesterol (3.21 +/- 0.11 vs. 2.97 +/- 0.14 nmol/L; P less than 0.01). No changes in anthropometric parameters or serum lipid levels occurred in the placebo group. Tissue sensitivity to insulin, assessed by the hyperinsulinemic-euglycemic clamp technique, did not change in either the placebo or DHEA groups. These results suggest that in normal men DHEA administration reduces body fat, increases muscle mass, and reduces serum low density lipoprotein cholesterol levels. Tissue sensitivity to insulin was unaffected by short term DHEA administration.
为评估脱氢表雄酮（DHEA）对体脂量、血清脂质水平及组织胰岛素敏感性的影响，在一项随机双盲研究中，给5名正常男性服用安慰剂，另5名正常男性口服DHEA[1600毫克/天（554.7毫摩尔/天）]，为期28天。在DHEA组，血清DHEA-S水平升高了2.5至3.5倍，血清雄烯二酮均值（±标准误）从4.3±0.6升至8.6±1.2纳摩尔/升（配对t检验，P<0.004），但血清总睾酮、游离睾酮、性激素结合球蛋白、雌二醇和雌酮水平未发生变化。在DHEA组，平均体脂百分比下降了31%，体重无变化。这表明脂肪量的减少与肌肉量的增加有关。服用DHEA还导致血清总胆固醇浓度均值下降（4.82±0.21对4.48±0.29纳摩尔/升；P<0.05），这几乎完全归因于血清低密度脂蛋白胆固醇均值下降了7.5%（3.21±0.11对2.97±0.14纳摩尔/升；P<0.01）。安慰剂组的人体测量参数或血清脂质水平未发生变化。通过高胰岛素-正血糖钳夹技术评估的组织胰岛素敏感性，在安慰剂组和DHEA组均未改变。这些结果表明，在正常男性中，服用DHEA可减少体脂、增加肌肉量并降低血清低密度脂蛋白胆固醇水平。短期服用DHEA对组织胰岛素敏感性无影响。
