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运动训练和牛蒡根（Arctium lappa L.）提取物均可改善代谢综合征老年女性的腹部肥胖和性激素。

Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones in elderly women with metabolic syndrome.

机构信息

Department of Sports Culture, College of the Arts, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Jung-gu, Seoul, 04620, Republic of Korea.

Division of Sports Neuroscience, Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8574, Japan.

出版信息

Sci Rep. 2021 Mar 4;11(1):5175. doi: 10.1038/s41598-021-84301-x.

DOI:10.1038/s41598-021-84301-x
PMID:33664334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7933410/
Abstract

The prevalence of metabolic syndrome (MS) is increasing among the elderly, and new lifestyle-based treatment strategies are warranted. We conducted a randomized, double-blind controlled trial of the effects of aquatic exercise (AE) and/or consumption of burdock root extract (BE) on body composition and serum sex hormones, i.e., testosterone, estradiol, sex hormone-binding globulin (SHBG), and dehydroepiandrosterone-sulfate (DHEA-S) in elderly women with MS. The percentage of abdominal fat was decreased in the AE group. Waist circumference was increased in the control (CON) group, but not in the other groups. SHBG and estradiol levels were enhanced by both AE and BE and correlated with changes in fat-related body composition. DHEA-S levels only increased in the BE group, which was consistent with changes in lean body mass. Testosterone levels decreased in the CON group, which correlated with changes in lean body mass, skeletal muscle mass, body fat, and waist circumference. Our findings suggested that the combined AE/BE intervention exerted no synergistic and/or additive effects on any sex-related outcome measures in elderly women with MS.

摘要

代谢综合征（MS）在老年人中的发病率正在增加，需要新的基于生活方式的治疗策略。我们进行了一项随机、双盲对照试验，研究了水疗（AE）和/或牛蒡根提取物（BE）对患有 MS 的老年女性的身体成分和血清性激素（即睾酮、雌二醇、性激素结合球蛋白（SHBG）和硫酸脱氢表雄酮（DHEA-S）的影响。AE 组的腹部脂肪百分比降低。腰围在对照组（CON）中增加，但在其他组中没有增加。AE 和 BE 均能提高 SHBG 和雌二醇水平，并与脂肪相关的身体成分变化相关。DHEA-S 水平仅在 BE 组中增加，这与瘦体重的变化一致。CON 组的睾酮水平下降，与瘦体重、骨骼肌量、体脂肪和腰围的变化相关。我们的研究结果表明，AE/BE 联合干预对患有 MS 的老年女性的任何与性别相关的结果指标均无协同和/或相加作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/7933410/316df8f76f4f/41598_2021_84301_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/7933410/25d528e76a66/41598_2021_84301_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/7933410/a043c45073ac/41598_2021_84301_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/7933410/316df8f76f4f/41598_2021_84301_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/7933410/25d528e76a66/41598_2021_84301_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/7933410/a043c45073ac/41598_2021_84301_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6876/7933410/316df8f76f4f/41598_2021_84301_Fig3_HTML.jpg

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Exercise training and burdock root (Arctium lappa L.) extract independently improve abdominal obesity and sex hormones in elderly women with metabolic syndrome.

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引用本文的文献

[1]
Anti-leishmanial effect of the hydroalcoholic extract of the leaves, roots and seeds of .

Avicenna J Phytomed. 2025

[2]
L. roots inhibit the intestinal inflammation of dietary obese rats through TLR4/NF-κB pathway.

Heliyon. 2023-11-4

[3]
Chlorogenic Acid from Burdock Roots Ameliorates Oleic Acid-Induced Steatosis in HepG2 Cells through AMPK/ACC/CPT-1 Pathway.

Molecules. 2023-10-25

[4]
The Combined Intervention of Aqua Exercise and Burdock Extract Synergistically Improved Arterial Stiffness: A Randomized, Double-Blind, Controlled Trial.

Metabolites. 2022-10-13

[5]
Aquatic Exercise Positively Affects Physiological Frailty among Postmenopausal Women: A Randomized Controlled Clinical Trial.

Healthcare (Basel). 2021-4-2

本文引用的文献

[1]
Supervised lifestyle intervention for people with metabolic syndrome improves outcomes and reduces individual risk factors of metabolic syndrome: A systematic review and meta-analysis.

Metabolism. 2019-10-28

[2]
Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal-based studies.

Phytother Res. 2019-6-24

[3]
Positive influence of aqua exercise and burdock extract intake on fitness factors and vascular regulation substances in elderly.

J Clin Biochem Nutr. 2019-1

[4]
Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages.

Mediators Inflamm. 2018-6-25

[5]
Effects of aquarobic exercise and burdock intake on serum blood lipids and vascular elasticity in Korean elderly women.

Exp Gerontol. 2017-11-14

[6]
The effect of exercise training on clinical outcomes in patients with the metabolic syndrome: a systematic review and meta-analysis.

Cardiovasc Diabetol. 2017-8-30

[7]
Relation between metabolic syndrome and body compositions among Chinese adolescents and adults from a large-scale population survey.

BMC Public Health. 2017-4-20

[8]
Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development.

Endocrinology. 2017-3-1

[9]
Antidiabetic, hypolipidemic and hepatoprotective effects of root's hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice.

Avicenna J Phytomed. 2017

[10]
Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials.

Breast Cancer Res. 2015-11-5

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