未分化结缔组织病患者中的抗DFS70自身抗体：前景如何？
Anti-DFS70 autoantibodies in undifferentiated connective tissue diseases subjects: what's on the horizon?
作者信息
Infantino Maria, Shovman Ora, Pérez Dolores, Manfredi Mariangela, Grossi Valentina, Benucci Maurizio, Gobbi Francesca Li, Bandinelli Francesca, Damiani Arianna, Moscato Paolo, Azoulay Danielle, Gilburd Boris, Shoenfeld Yehuda
机构信息
Laboratory of Immunology and Allergology, S. Giovanni di Dio Hospital, Florence, Italy.
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Aviv, Israel.
出版信息
Rheumatology (Oxford). 2018 Jul 1;57(7):1293-1298. doi: 10.1093/rheumatology/key012.
OBJECTIVE
The main objective was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role.
METHODS
Immunological and clinical records of 91 long-standing UCTD patients were studied. DFS pattern was determined using the IIF ANA test on HEp-2 cells and anti-DFS70 antibodies were tested by chemiluminescence assay and by DFS70 line immunoassay.
RESULTS
Twelve (13.2%) of 91 serum samples were positive for anti-DFS70 antibodies by chemiluminescence assay and line immunoassay. There was no statistical significance between the prevalence of anti-ENA and anti-DNA autoantibodies in patients with and without anti-DFS70 antibodies. No differences were found in the clinical characteristics of both groups. The presence of the anti-DFS70 antibodies was related to the younger age class.
CONCLUSION
The high prevalence of anti-DFS70 antibodies in the UCTD patients suggested the potential role of these autoantibodies as a marker in the evolution of UCTD to CTD.
目的
主要目的是确定未分化结缔组织病（UCTD）稳定人群中抗致密细颗粒（DFS70）抗体的患病率，以更好地明确其潜在作用。
方法
研究了91例长期UCTD患者的免疫学和临床记录。使用HEp-2细胞上的间接免疫荧光抗核抗体（IIF ANA）试验确定DFS模式，并通过化学发光法和DFS70线性免疫分析法检测抗DFS70抗体。
结果
通过化学发光法和线性免疫分析法，91份血清样本中有12份（13.2%）抗DFS70抗体呈阳性。有和没有抗DFS70抗体的患者中，抗可提取核抗原（ENA）和抗脱氧核糖核酸（DNA）自身抗体的患病率之间无统计学意义。两组的临床特征未发现差异。抗DFS70抗体的存在与较年轻年龄组有关。
结论
UCTD患者中抗DFS70抗体的高患病率表明这些自身抗体作为UCTD向结缔组织病（CTD）演变的标志物的潜在作用。
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