Department of Dermatology and Venereology, Medical University of Łódź, Lodz, Poland.
Department of Dermatology, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Immun Inflamm Dis. 2023 Sep;11(9):e1026. doi: 10.1002/iid3.1026.
Antinuclear antibodies (ANAs) are regarded as a hallmark of connective tissue diseases (CTDs) and play a key role in their diagnosis, but the value of some particular antibodies in management of patients and the disease prognosis is controversial. The mechanism underlying the production of ANAs in CTDs, other chronic inflammatory conditions and even in healthy people, is not completely elucidated. Anti-DFS70 antibodies connected with the dense fine speckled autoantigen of 70 kD, known as the lens epithelium-derived growth factor p75, are a subgroup of ANAs. Their presence and coexistence with other antibodies and their clinical significance are the matter of debate.
Based on literature data, the authors focused on current knowledge explaining the role of anti-DFS70 antibodies in selected CTDs.
However, the literature data is ambiguous and does not fully support the validity of the anti-DFS70 assay for a specific CTD diagnosis. Most researchers claim that the presence of anti-DFS70 as the only one usually exclude the diagnosis of CTD. Nevertheless, its coexistence with other ANAs is not an excluding factor but has predictive value due to more favorable course of CTD. Such situations may also suggest an enhanced risk of the development of a CTD in the future.
Although more studies are needed in this field, it seems reasonable to ascertain the presence of anti-DFS70 in routine clinical practice.
抗核抗体（ANA）被认为是结缔组织病（CTD）的标志，在其诊断中起着关键作用，但某些特定抗体在患者管理和疾病预后中的价值存在争议。CTD、其他慢性炎症性疾病，甚至健康人群中产生 ANA 的机制尚未完全阐明。与 70kD 致密细斑点自身抗原相关的抗 DFS70 抗体，称为晶状体上皮衍生生长因子 p75，是 ANA 的亚群。它们的存在及其与其他抗体的共存及其临床意义是争论的问题。
基于文献数据，作者重点介绍了目前解释抗 DFS70 抗体在选定 CTD 中作用的知识。
然而，文献数据存在分歧，并不完全支持抗 DFS70 检测对特定 CTD 诊断的有效性。大多数研究人员声称，抗 DFS70 的存在通常排除 CTD 的诊断。然而，其与其他 ANA 的共存并不是排除因素，而是具有预测价值，因为 CTD 的病程更为有利。这种情况也可能表明未来发生 CTD 的风险增加。
尽管在这一领域需要更多的研究，但在常规临床实践中确定抗 DFS70 的存在似乎是合理的。
