Khalid Shamaila, Shaikh Fuad, Moeen Sara
Department of Pharmacology, DMC, Dow University of Health Sciences, Karachi, Pakistan.
Department of Anatomy DMC, Dow University of Health Sciences, Karachi, Pakistan.
Pak J Pharm Sci. 2018 Mar;31(2):405-409.
Iron deficiency anemia (IDA) during pregnancy not only results in the disturbance of hematological parameters but has been found to be an additional cause of oxidative stress (OS). Moreover, oral iron for IDA during pregnancy has been found to worsen the condition. Present study aims to detect any alteration in glutathione peroxidase (GSH-Px) activity as an enzymatic anti-oxidant and its association with oral iron supplements. For study, 40 anemic pregnant women were prescribed with 200mg ferrous sulphate for 12 weeks (wks). A significant improvement in hemoglobin (Hb) and serum ferritin concentration (SFC) was seen after treatment (p<0.05). In contrast to the values for hematological parameters, GSH-PX was found to be same for control and anemic groups before iron supplements (p>0.05). A significant decrease in GSH-PX levels of anemic women was seen after iron therapy when compared with both the initial values and the control group (p<0.05). We found a positive association between oral iron administration and OS. Our results showed a strong association between oral iron supplements and SFC which supports the iron overload theory. It is therefore concluded that OS is associated with oral iron supplements during pregnancy.
孕期缺铁性贫血（IDA）不仅会导致血液学参数紊乱，还被发现是氧化应激（OS）的另一个原因。此外，已发现孕期用于治疗IDA的口服铁剂会使病情恶化。本研究旨在检测作为酶促抗氧化剂的谷胱甘肽过氧化物酶（GSH-Px）活性的任何变化及其与口服铁剂补充的关联。在本研究中，40名贫血孕妇被给予200毫克硫酸亚铁，为期12周。治疗后血红蛋白（Hb）和血清铁蛋白浓度（SFC）有显著改善（p<0.05）。与血液学参数值相反，在补充铁剂之前，对照组和贫血组的GSH-PX值相同（p>0.05）。与初始值和对照组相比，铁剂治疗后贫血女性的GSH-PX水平显著降低（p<0.05）。我们发现口服铁剂与氧化应激之间存在正相关。我们的结果显示口服铁剂补充与血清铁蛋白浓度之间存在强关联，这支持了铁过载理论。因此得出结论，孕期氧化应激与口服铁剂补充有关。
