Han Xiu X, Sun Yong Y, Ma Ai G, Yang Fang, Zhang Feng Z, Jiang Dian C, Li Yong
Institute of Human Nutrition, Medical College of Qingdao University, China.
Asia Pac J Clin Nutr. 2011;20(4):514-20.
Iron is important general well being, to prevent or treat anemia, and is a cofactor of many enzymes in the anti-oxidant process. Effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA) and ferrous sulfate on iron bioavailability and oxidative stress in anemic pregnant women was evaluated. A 2-month randomized controlled trial was conducted on 153 anemic pregnant women, with 80 <= Hb <110 g/L. They were randomly allocated to three groups: group C (n=51) was the placebo control group, group I (n=51) was supplemented daily with 60 mg iron as ferrous sulfate, and group IE (n=51) with 60 mg iron as NaFeEDTA. Blood samples were collected before and at the end of the intervention for measurements of hematological indices and oxidative stress parameters. Considerable increases of hematologic indicators were observed: 20.5 and 21.8 g/L for Hb (both p values <0.001); 4.81 and 7.19 μmol/L for plasma iron (both p values <0.001), 2.63 and 8.99 μg /L for ferritin (both p values <0.05) in I and IE groups, respectively, compared with the control group. Glutathione peroxidase (GSH-Px) activities increased by 32.6 and 75.3 IU/ml, and malondialdehyde (MDA) levels decreased by 0.70 and 1.12 μmol/L in I and IE groups, compared with the C group (p values <0.05). Moreover, differences of plasma iron, ferritin and GSH-Px activity were 2.38 μmol/L, 6.36 μg /L and 42.7 IU/ml were also significantly greater in the IE group than in the I group. Moderate iron supplementation may be beneficial to improving iron deficiency and oxidative stress, and NaFeEDTA is better than ferrous sulfate.
铁对于总体健康很重要，有助于预防或治疗贫血，并且是抗氧化过程中许多酶的辅助因子。评估了乙二胺四乙酸铁钠（NaFeEDTA）和硫酸亚铁对贫血孕妇铁生物利用度和氧化应激的影响。对153名贫血孕妇进行了一项为期2个月的随机对照试验，她们的血红蛋白（Hb）水平为80≤Hb＜110g/L。她们被随机分为三组：C组（n = 51）为安慰剂对照组，I组（n = 51）每天补充60mg硫酸亚铁形式的铁，IE组（n = 51）每天补充60mg NaFeEDTA形式的铁。在干预前后采集血样，以测量血液学指标和氧化应激参数。观察到血液学指标有显著增加：与对照组相比，I组和IE组的血红蛋白分别增加了20.5和21.8g/L（p值均＜0.001）；血浆铁分别增加了4.81和7.19μmol/L（p值均＜0.001），铁蛋白分别增加了[2.63和8.99μg/L（p值均＜0.05）]。与C组相比，I组和IE组的谷胱甘肽过氧化物酶（GSH-Px）活性分别增加了32.6和75.3IU/ml，丙二醛（MDA）水平分别降低了0.70和1.12μmol/L（p值＜0.05）。此外IE组的血浆铁、铁蛋白和GSH-Px活性差异分别为2.38μmol/L、6.36μg/L和42.7IU/ml，也显著高于I组。适度补充铁可能有助于改善缺铁和氧化应激，且NaFeEDTA比硫酸亚铁效果更好。
