Tsuchiya T
Dept. of Radiation Biology & Health, Univ. of Occupational and Environmental Health.
Gan No Rinsho. 1987 Oct;33(13):1684-6.
In this previous meeting, author reported that specific anti-tumor T cells, perhaps helper T cells, are induced in host mice after local irradiation to tumor. Immunostimulators were used following local irradiation to tumor. However, because suppressor T cells were also stimulated by these drugs, cyclophosphamide was used to suppress suppressor T cells. The results indicate that the combined use of immunostimulator and suppressor of suppressor T cells is very effective in radiation therapy. In the combined use of these drugs, the following three factors are very important: 1) whether the drug is administered before or after radiation, 2) the time interval between administrations of immunostimulator and suppressor T cells and local irradiation, and 3) dosage. Good effects were not obtained when dosage exceeded appropriate levels. The relationships among these factors are critical.
在之前的会议中，作者报告称，在对肿瘤进行局部照射后，宿主小鼠体内会诱导产生特异性抗肿瘤T细胞，可能是辅助性T细胞。在对肿瘤进行局部照射后使用了免疫刺激剂。然而，由于这些药物也会刺激抑制性T细胞，因此使用环磷酰胺来抑制抑制性T细胞。结果表明，免疫刺激剂与抑制性T细胞抑制剂联合使用在放射治疗中非常有效。在联合使用这些药物时，以下三个因素非常重要：1）药物在放疗之前还是之后给药；2）免疫刺激剂、抑制性T细胞抑制剂与局部照射之间的时间间隔；3）剂量。当剂量超过适当水平时，无法获得良好效果。这些因素之间的关系至关重要。
