Norimura T, Kunugita N, Dohi S, Mukae S, Tsuchiya T
Dept. of Radiation Biology & Health, Univ. of Occupational and Environmental Health.
Gan No Rinsho. 1988 Oct;34(13):1811-5.
We have previously demonstrated that specific antitumor cell-mediated immunity in host mice was induced or enhanced by local irradiation to tumor. In this study, the immunological status of host mice with transplanted tumor were modified by using OK-432 as immunostimulator and cyclophosphamide as suppressor of suppressor T-cells before and/or after local irradiation to tumor. The results indicate that the combined use of immunomodifier and radiation is more effective in the tumor radiotherapy. Three factors as follows: the interval of drug and radiation, the times of treatments and dose of immunostimulator and immunosuppressor, are very important in these combined therapy.
我们之前已经证明，对肿瘤进行局部照射可诱导或增强宿主小鼠体内特异性抗肿瘤细胞介导的免疫反应。在本研究中，在对肿瘤进行局部照射之前和/或之后，使用OK-432作为免疫刺激剂，环磷酰胺作为抑制性T细胞的抑制剂，来改变荷瘤宿主小鼠的免疫状态。结果表明，免疫调节剂与放疗联合使用在肿瘤放射治疗中更有效。药物与放疗的间隔时间、治疗次数以及免疫刺激剂和免疫抑制剂的剂量这三个因素在这些联合治疗中非常重要。
