健脾解毒中药在晚期结直肠癌患者中的应用：一项系统评价与Meta分析

Use of Jianpi Jiedu Herbs in Patients with Advanced Colorectal Cancer: A Systematic Review and Meta-Analysis.

作者信息

Zhang Shaofan, Shi Li, Mao Dan, Peng Weijun, Sheng Chenxia, Ding Chenchen, Lin Fengxia, Lei Caiyun, Zhang Sifang

机构信息

Department of Integrated Chinese and Western Medicine, The Second Hospital of Xiangya, Central South University, Changsha 410008, China.

Department of Cardiology, Affiliated Bao'an TCM Hospital, Guangzhou University of Traditional Chinese Medicine, Shenzhen, Guangdong, China.

出版信息

Evid Based Complement Alternat Med. 2018 Jan 29;2018:6180810. doi: 10.1155/2018/6180810. eCollection 2018.

OBJECTIVE

To systematically review the effect of invigorating Pi and detoxification (Jianpi Jiedu, (JPJD)) herbs in advanced colorectal cancer (CRC) patients receiving chemotherapy.

METHODS

Three English and four Chinese databases were searched. Literature was screened by EndNote X7 and data were analyzed by RevMan 5.2.

RESULTS

This review comprised 12 randomized clinical studies of 701 patients. The results showed that JPJD herbs improved the therapeutic effect on Chinese medicine symptoms [risk ratio (RR) = 1.59; 95% confidence interval (CI): 1.35~~1.88] and Karnofsky performance score [RR = 2.07; 95% CI: 1.52~~2.82] for advanced CRC patients receiving chemotherapy, lowered the Chinese medicine symptoms' score [weighted mean difference = -2.44; 95% CI: -3.23~~-1.64], reduced the incidence of nausea and vomiting [RR = 0.23; 95% CI: 0.11~~0.49], improved platelet at toxicity grades III-IV [odds ratio = 0.29; 95% CI: 0.12~~0.74] and I-IV [RR = 0.65; 95% CI: 0.51~~0.82], and improved white blood cell at toxicity grades III-IV [RR = 0.37; 95% CI: 0.23~~0.58] and I-IV [RR = 0.69; 95% CI: 0.60~~0.79]. However, the results showed no significant effect on tumor response.

CONCLUSION

JPJD herbs can improve quality of life, relieve symptoms, and reduce adverse events of advanced CRC patients receiving chemotherapy.

目的

系统评价健脾解毒中药对晚期结直肠癌（CRC）化疗患者的影响。

方法

检索了3个英文数据库和4个中文数据库。通过EndNote X7筛选文献，并用RevMan 5.2分析数据。

结果

本综述纳入了701例患者的12项随机临床研究。结果显示，健脾解毒中药可提高晚期CRC化疗患者的中医症状治疗效果[风险比（RR）=1.59；95%置信区间（CI）：1.35~~1.88]和卡氏功能状态评分[RR = 2.07；95% CI：1.52~~2.82]，降低中医症状评分[加权均数差=-2.44；95% CI：-3.23~~-1.64]，降低恶心呕吐发生率[RR = 0.23；95% CI：0.11~~0.49]，改善Ⅲ-Ⅳ度毒性时的血小板水平[比值比=0.29；95% CI：0.12~~0.74]和Ⅰ-Ⅳ度毒性时的血小板水平[RR = 0.65；95% CI：0.51~~0.82]，改善Ⅲ-Ⅳ度毒性时的白细胞水平[RR = 0.37；95% CI：0.23~~0.58]和Ⅰ-Ⅳ度毒性时的白细胞水平[RR = 0.69；95% CI：0.60~~0.79]。然而，结果显示对肿瘤反应无显著影响。