Klausen B, Hougen H P
Department of Oral Diagnosis, Royal Dental College, Copenhagen, Denmark.
Lab Anim. 1987 Oct;21(4):342-7. doi: 10.1258/002367787781363318.
Four groups of inbred male LEW rats were examined: A, germfree athymic; B, specified pathogen free (SPF) athymic; C, germfree euthymic; D, SPF euthymic. All animals were killed at 18 weeks and compared with respect to body weight, histological appearance and cell density of the lymphoid organs, haematological values and differential counts of bone marrow, peripheral blood and lymph. Athymic rats had a lower body weight, less densely populated lymphoid organs, and fewer lymphocytes in the blood and lymph compared with euthymic animals. No difference was seen between athymic rats under germfree and SPF conditions, and in general the differences between athymic and euthymic animals were less pronounced under germfree conditions.
对四组近交系雄性LEW大鼠进行了检查：A组，无菌无胸腺；B组，无特定病原体（SPF）无胸腺；C组，无菌有胸腺；D组，SPF有胸腺。所有动物在18周时处死，并比较体重、淋巴器官的组织学外观和细胞密度、血液学值以及骨髓、外周血和淋巴的分类计数。与有胸腺动物相比，无胸腺大鼠体重较低，淋巴器官细胞密度较低，血液和淋巴中的淋巴细胞较少。无菌和SPF条件下的无胸腺大鼠之间未见差异，一般而言，无菌条件下无胸腺和有胸腺动物之间的差异不太明显。
