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心血管功能障碍与肝移植

Cardiovascular dysfunction and liver transplantation.

作者信息

Kwon Hye-Mee, Hwang Gyu-Sam

机构信息

Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

Korean J Anesthesiol. 2018 Apr;71(2):85-91. doi: 10.4097/kjae.2018.71.2.85. Epub 2018 Apr 2.

Abstract

Cardiovascular complications have emerged as the leading cause of death after liver transplantation, particularly among those with advanced liver cirrhosis. Therefore, a thorough and accurate cardiovascular evaluation with clear comprehension of cirrhotic cardiomyopathy is recommended for optimal anesthetic management. However, cirrhotic patients manifest cardiac dysfunction concomitant with pronounced systemic hemodynamic changes, characterized by hyperdynamic circulation such as increased cardiac output, high heart rate, and decreased systemic vascular resistance. These unique features mask significant manifestations of cardiac dysfunction at rest, which makes it difficult to accurately evaluate cardiovascular status. In this review, we have summarized the current knowledge of heart and liver interactions, focusing on the usefulness and limitations of cardiac evaluation tools for identifying high-risk patients.

摘要

心血管并发症已成为肝移植后主要的死亡原因,在晚期肝硬化患者中尤为如此。因此,为了实现最佳麻醉管理,建议进行全面、准确的心血管评估,并清楚了解肝硬化性心肌病。然而,肝硬化患者表现出心脏功能障碍并伴有明显的全身血流动力学变化,其特征为高动力循环,如心输出量增加、心率加快和全身血管阻力降低。这些独特特征掩盖了静息时心脏功能障碍的显著表现,使得准确评估心血管状况变得困难。在本综述中,我们总结了目前关于心脏与肝脏相互作用的知识,重点关注用于识别高危患者的心脏评估工具的实用性和局限性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92fb/5903113/e91031ce864d/kjae-2018-71-2-85f1.jpg

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